Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib

Ronald L. Paquette, John Nicoll, Meenal Chalukya, Lucas Gondek, Monika Jasek, Charles L. Sawyers, Neil P. Shah, Jaroslaw Maciejewski

Research output: Contribution to journalArticle

Abstract

A clonal cytogenetic abnormality was observed in Philadelphia chromosome-negative bone marrow cells of 6/27 chronic myeloid leukemia patients (+8 in 4, -7 in 1, and 20q- in 1) with dasatinib-induced remissions. The X-linked human androgen receptor gene assay demonstrated clonality in one additional patient. Single nucleotide polymorphism array analysis revealed somatic uniparental disomy involving chromosome 17(p12-pter) in another patient. The TP53 gene had a 5′ splice site deletion of exon 6 that caused alternative splicing, frame shifting and introduction of a premature stop codon. After three years, no patient developed myelodysplastic syndrome or acute myeloid leukemia.

Original languageEnglish (US)
Pages (from-to)708-713
Number of pages6
JournalLeukemia Research
Volume34
Issue number6
DOIs
StatePublished - Jun 1 2010

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Keywords

  • Chronic myeloid leukemia
  • Cytogenetics
  • Dasatinib
  • Myelodysplastic syndrome
  • Single nucleotide polymorphism array
  • TP53

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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