Clonal chromosomal abnormalities in Fanconi's anaemia: What do they really mean?

B. P. Alter, A. Scalise, J. McCombs, V. Najfeld

Research output: Contribution to journalArticle

Abstract

Patients with Fanconi's anaemia (FA) have aplastic anaemia, leukaemia, myelodysplasia and tumours. Since leukaemia has a very poor prognosis, it is desirable to identify high-risk patients. To determine the significance of clonal marrow chromosomal abnormalities we began a prospective study in 17 patients: five were normal, eight aplastic, and four myelodysplastic. Three of 11 with adequate cytogenetics had transient abnormal clones. None had leukaemia at 3-24 months. Changing cytogenetic patterns may not be related to leukaemic evolution in patients with a DNA repair defect.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalBritish Journal of Haematology
Volume85
Issue number3
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Alter, B. P., Scalise, A., McCombs, J., & Najfeld, V. (1993). Clonal chromosomal abnormalities in Fanconi's anaemia: What do they really mean? British Journal of Haematology, 85(3), 627-630.