TY - JOUR
T1 - Clonal characteristics of fibrous plaques and fatty streaks from human aortas
AU - Pearson, T. A.
AU - Wang, A.
AU - Solez, K.
AU - Heptinstall, R. H.
PY - 1975
Y1 - 1975
N2 - Using isoenzymes of glucose 6 phosphate dehydrogenase (G 6 PD) as cellular markers, a study was made of atherosclerotic fibrous plaques and fatty streaks in aortas of black women heterozygous for G 6 PD. Of 29 fibrous plaques, 26 (89.7%) contained only one isoenzyme (17, A; 9, B), the other three containing both A and B. Of 28 fatty streaks, five (17.8%) contained only one isoenzyme (2, A; 3, B), the remaining 23 containing both A and B. Normal uninvolved aorta contained both A and B isoenzymes in 99 of 101 samples. These results confirm the monoclonal character of atherosclerotic fibrous plaques; this stands in contrast to the fatty streaks which most commonly contain the two isoenzymes. The studies on the fatty streaks are inconclusive at this stage in determining whether the streak is the forerunner of the fibrous plaque.
AB - Using isoenzymes of glucose 6 phosphate dehydrogenase (G 6 PD) as cellular markers, a study was made of atherosclerotic fibrous plaques and fatty streaks in aortas of black women heterozygous for G 6 PD. Of 29 fibrous plaques, 26 (89.7%) contained only one isoenzyme (17, A; 9, B), the other three containing both A and B. Of 28 fatty streaks, five (17.8%) contained only one isoenzyme (2, A; 3, B), the remaining 23 containing both A and B. Normal uninvolved aorta contained both A and B isoenzymes in 99 of 101 samples. These results confirm the monoclonal character of atherosclerotic fibrous plaques; this stands in contrast to the fatty streaks which most commonly contain the two isoenzymes. The studies on the fatty streaks are inconclusive at this stage in determining whether the streak is the forerunner of the fibrous plaque.
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M3 - Article
C2 - 1190295
AN - SCOPUS:0016721467
SN - 0002-9440
VL - 81
SP - 379
EP - 387
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 2
ER -