Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare

Thomas A. Pearson, John Dillman, Kevin J. Williams, Jon A. Wolff, Robert John Adams, Kim Solez, Robert H. Heptinstall, Haqvin Malmros, Nils Sternby

Research output: Contribution to journalArticle

Abstract

The female hybrid hare (Lepus timidus × Lepus europaeus) is heterozygous for eletrophoreticatty separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.

Original languageEnglish (US)
Pages (from-to)1423-1425
Number of pages3
JournalScience
Volume206
Issue number4425
StatePublished - 1979

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Isoenzymes
Glucosephosphate Dehydrogenase
Atherosclerotic Plaques
Catheters
Cholesterol

ASJC Scopus subject areas

  • General

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Pearson, T. A., Dillman, J., Williams, K. J., Wolff, J. A., Adams, R. J., Solez, K., ... Sternby, N. (1979). Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare. Science, 206(4425), 1423-1425.

Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare. / Pearson, Thomas A.; Dillman, John; Williams, Kevin J.; Wolff, Jon A.; Adams, Robert John; Solez, Kim; Heptinstall, Robert H.; Malmros, Haqvin; Sternby, Nils.

In: Science, Vol. 206, No. 4425, 1979, p. 1423-1425.

Research output: Contribution to journalArticle

Pearson, TA, Dillman, J, Williams, KJ, Wolff, JA, Adams, RJ, Solez, K, Heptinstall, RH, Malmros, H & Sternby, N 1979, 'Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare', Science, vol. 206, no. 4425, pp. 1423-1425.
Pearson TA, Dillman J, Williams KJ, Wolff JA, Adams RJ, Solez K et al. Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare. Science. 1979;206(4425):1423-1425.
Pearson, Thomas A. ; Dillman, John ; Williams, Kevin J. ; Wolff, Jon A. ; Adams, Robert John ; Solez, Kim ; Heptinstall, Robert H. ; Malmros, Haqvin ; Sternby, Nils. / Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare. In: Science. 1979 ; Vol. 206, No. 4425. pp. 1423-1425.
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