Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare

Thomas A. Pearson, John Dillman, Kevin J. Williams, Jon A. Wolff, Robert Adams, Kim Solez, Robert H. Heptinstall, Haqvin Malmros, Nils Sternby

Research output: Contribution to journalArticle

Abstract

The female hybrid hare (Lepus timidus × Lepus europaeus) is heterozygous for eletrophoreticatty separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.

Original languageEnglish (US)
Pages (from-to)1423-1425
Number of pages3
JournalScience
Volume206
Issue number4425
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • General

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    Pearson, T. A., Dillman, J., Williams, K. J., Wolff, J. A., Adams, R., Solez, K., Heptinstall, R. H., Malmros, H., & Sternby, N. (1979). Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare. Science, 206(4425), 1423-1425. https://doi.org/10.1126/science.505016