Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare

Thomas A. Pearson; John Dillman; Kevin J. Williams; Jon A. Wolff; Robert Adams; Kim Solez; Robert H. Heptinstall; Haqvin Malmros; Nils Sternby

doi:10.1126/science.505016

Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare

Thomas A. Pearson, John Dillman, Kevin J. Williams, Jon A. Wolff, Robert Adams, Kim Solez, Robert H. Heptinstall, Haqvin Malmros, Nils Sternby

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The female hybrid hare (Lepus timidus × Lepus europaeus) is heterozygous for eletrophoreticatty separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.

Original language	English (US)
Pages (from-to)	1423-1425
Number of pages	3
Journal	Science
Volume	206
Issue number	4425
DOIs	https://doi.org/10.1126/science.505016
State	Published - 1979

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title = "Clonal characteristics of experimentally induced {"} atherosclerotic{"} lesions in the hybrid hare",

abstract = "The female hybrid hare (Lepus timidus × Lepus europaeus) is heterozygous for eletrophoreticatty separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.",

author = "Pearson, {Thomas A.} and John Dillman and Williams, {Kevin J.} and Wolff, {Jon A.} and Robert Adams and Kim Solez and Heptinstall, {Robert H.} and Haqvin Malmros and Nils Sternby",

year = "1979",

doi = "10.1126/science.505016",

language = "English (US)",

volume = "206",

pages = "1423--1425",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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T1 - Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare

AU - Pearson, Thomas A.

AU - Dillman, John

AU - Williams, Kevin J.

AU - Wolff, Jon A.

AU - Adams, Robert

AU - Solez, Kim

AU - Heptinstall, Robert H.

AU - Malmros, Haqvin

AU - Sternby, Nils

PY - 1979

Y1 - 1979

N2 - The female hybrid hare (Lepus timidus × Lepus europaeus) is heterozygous for eletrophoreticatty separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.

AB - The female hybrid hare (Lepus timidus × Lepus europaeus) is heterozygous for eletrophoreticatty separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.

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SP - 1423

EP - 1425

JO - Science

JF - Science

IS - 4425

ER -

Clonal characteristics of experimentally induced " atherosclerotic" lesions in the hybrid hare

Abstract

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