Clonal characteristics of cutaneous T cell lymphomas: Cytogenetic evidence from blood, lymph nodes, and skin

P. C. Nowell, J. B. Finan, E. C. Vonderheid

Research output: Contribution to journalArticle

Abstract

Chromosome studies were done on mitogen-stimulated lymphocytes from one or more tissues (blood, lymph nodes, skin lesions) in 15 patients with mycosis fungoides or Sezary syndrome. A cytogenetically abnormal clone was found in 10 individuals, including 6 with data from several tissues. In 4 cases the same aberrant clone was identified in a skin lesion as well as in blood and/or lymph node. The abnormal chromosome patterns ranged from hypodiploid to hypertetraploid, and there was no evidence of unrelated karyotypically-altered lines at different sites. A 6q- chromosome, previously reported in acute lymphocytic leukemia, was found in 2 patients. The results support the concept that cutaneous T cell lymphomas (CTCL) are clonal disorders, presumably unifocal in origin, with the skin lesions populated by cells from the same neoplastic clone that involves lymph nodes and blood.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalJournal of Investigative Dermatology
Volume78
Issue number1
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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