Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation

James R Brasic, J. Y. Barnett, D. Kaplan, B. B. Sheitman, P. Aisemberg, R. T. Lafargue, S. Kowalik, A. Clark, M. O. Tsaltas, J. G. Young

Research output: Contribution to journalArticle

Abstract

In an open, nonblind clinical trial, clomipramine reduced adventitious movementsand compulsions in five previously medicated prepubertal boys with autistic disorder andsevere mental retardation. Poorly adapted rating scales, interrater variability, subjectheterogeneity, different treatment histories, and environmental stresses confounded the assessment of treatment effects.

Original languageEnglish (US)
Pages (from-to)1309-1312
Number of pages4
JournalNeurology
Volume44
Issue number7
StatePublished - 1994
Externally publishedYes

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Clomipramine
Autistic Disorder
Intellectual Disability
Clinical Trials
Therapeutics
Mental Retardation
Rating Scales
Boys
History
Treatment Effects

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Brasic, J. R., Barnett, J. Y., Kaplan, D., Sheitman, B. B., Aisemberg, P., Lafargue, R. T., ... Young, J. G. (1994). Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation. Neurology, 44(7), 1309-1312.

Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation. / Brasic, James R; Barnett, J. Y.; Kaplan, D.; Sheitman, B. B.; Aisemberg, P.; Lafargue, R. T.; Kowalik, S.; Clark, A.; Tsaltas, M. O.; Young, J. G.

In: Neurology, Vol. 44, No. 7, 1994, p. 1309-1312.

Research output: Contribution to journalArticle

Brasic, JR, Barnett, JY, Kaplan, D, Sheitman, BB, Aisemberg, P, Lafargue, RT, Kowalik, S, Clark, A, Tsaltas, MO & Young, JG 1994, 'Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation', Neurology, vol. 44, no. 7, pp. 1309-1312.
Brasic, James R ; Barnett, J. Y. ; Kaplan, D. ; Sheitman, B. B. ; Aisemberg, P. ; Lafargue, R. T. ; Kowalik, S. ; Clark, A. ; Tsaltas, M. O. ; Young, J. G. / Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation. In: Neurology. 1994 ; Vol. 44, No. 7. pp. 1309-1312.
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