Clinicopathological features and prognosis of gastric cardia adenocarcinoma: A multi-institutional U.S. study

Neda Amini; Gaya Spolverato; Yuhree Kim; Malcolm H. Squires; George A. Poultsides; Ryan Fields; Carl Schmidt; Sharon M. Weber; Konstantinos Votanopoulos; Shishir K. Maithel; Timothy M. Pawlik

doi:10.1002/jso.23799

Clinicopathological features and prognosis of gastric cardia adenocarcinoma: A multi-institutional U.S. study

Neda Amini, Gaya Spolverato, Yuhree Kim, Malcolm H. Squires, George A. Poultsides, Ryan Fields, Carl Schmidt, Sharon M. Weber, Konstantinos Votanopoulos, Shishir K. Maithel, Timothy M. Pawlik

School of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Background and Objectives: Potential differences in presentation and outcome of patients with gastric cardia adenocarcinoma (GCA) and noncardia adenocarcinoma may exist. The aim of the present study was to compare the clinicopathological characteristics and the prognosis of GCA versus non-cardia adenocarcinoma. Method: Patients with gastric adenocarcinoma who underwent gastric resection between 2000-2012 were identified. Clinicopathological characteristics and outcomes were analyzed based on tumor site using a 1:2 matched-control, as well as a multivariable Cox model. Results: Among 743 patients, 80 (10.7%) patients were diagnosed with GCA. Patients with GCA were more likely to have intestinal tumor type (GCA: 80.4% versus non-cardia: 64.2%, P=0.04) or advanced AJCC T stage tumors (GCA 71.8% versus non-cardia 59.2%, P=0.03). GCA patients more likely underwent a total gastrectomy (GCA: 85.7% vs. non-cardia: 39.8%) and had a longer length-of-stay (GCA: 10 days vs. noncardia: 8 days) (both P

Original language	English (US)
Pages (from-to)	285-292
Number of pages	8
Journal	Journal of Surgical Oncology
Volume	111
Issue number	3
DOIs	https://doi.org/10.1002/jso.23799
State	Published - Mar 1 2015

Keywords

Gastric adenocarcinoma
Gastric cardia cancer
Outcomes
Surgery

ASJC Scopus subject areas

Surgery
Oncology
General Medicine

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10.1002/jso.23799

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title = "Clinicopathological features and prognosis of gastric cardia adenocarcinoma: A multi-institutional U.S. study",

abstract = "Background and Objectives: Potential differences in presentation and outcome of patients with gastric cardia adenocarcinoma (GCA) and noncardia adenocarcinoma may exist. The aim of the present study was to compare the clinicopathological characteristics and the prognosis of GCA versus non-cardia adenocarcinoma. Method: Patients with gastric adenocarcinoma who underwent gastric resection between 2000-2012 were identified. Clinicopathological characteristics and outcomes were analyzed based on tumor site using a 1:2 matched-control, as well as a multivariable Cox model. Results: Among 743 patients, 80 (10.7%) patients were diagnosed with GCA. Patients with GCA were more likely to have intestinal tumor type (GCA: 80.4% versus non-cardia: 64.2%, P=0.04) or advanced AJCC T stage tumors (GCA 71.8% versus non-cardia 59.2%, P=0.03). GCA patients more likely underwent a total gastrectomy (GCA: 85.7% vs. non-cardia: 39.8%) and had a longer length-of-stay (GCA: 10 days vs. noncardia: 8 days) (both P",

keywords = "Gastric adenocarcinoma, Gastric cardia cancer, Outcomes, Surgery",

author = "Neda Amini and Gaya Spolverato and Yuhree Kim and Squires, {Malcolm H.} and Poultsides, {George A.} and Ryan Fields and Carl Schmidt and Weber, {Sharon M.} and Konstantinos Votanopoulos and Maithel, {Shishir K.} and Pawlik, {Timothy M.}",

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AU - Amini, Neda

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AU - Kim, Yuhree

AU - Squires, Malcolm H.

AU - Poultsides, George A.

AU - Fields, Ryan

AU - Schmidt, Carl

AU - Weber, Sharon M.

AU - Votanopoulos, Konstantinos

AU - Maithel, Shishir K.

AU - Pawlik, Timothy M.

PY - 2015/3/1

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N2 - Background and Objectives: Potential differences in presentation and outcome of patients with gastric cardia adenocarcinoma (GCA) and noncardia adenocarcinoma may exist. The aim of the present study was to compare the clinicopathological characteristics and the prognosis of GCA versus non-cardia adenocarcinoma. Method: Patients with gastric adenocarcinoma who underwent gastric resection between 2000-2012 were identified. Clinicopathological characteristics and outcomes were analyzed based on tumor site using a 1:2 matched-control, as well as a multivariable Cox model. Results: Among 743 patients, 80 (10.7%) patients were diagnosed with GCA. Patients with GCA were more likely to have intestinal tumor type (GCA: 80.4% versus non-cardia: 64.2%, P=0.04) or advanced AJCC T stage tumors (GCA 71.8% versus non-cardia 59.2%, P=0.03). GCA patients more likely underwent a total gastrectomy (GCA: 85.7% vs. non-cardia: 39.8%) and had a longer length-of-stay (GCA: 10 days vs. noncardia: 8 days) (both P

AB - Background and Objectives: Potential differences in presentation and outcome of patients with gastric cardia adenocarcinoma (GCA) and noncardia adenocarcinoma may exist. The aim of the present study was to compare the clinicopathological characteristics and the prognosis of GCA versus non-cardia adenocarcinoma. Method: Patients with gastric adenocarcinoma who underwent gastric resection between 2000-2012 were identified. Clinicopathological characteristics and outcomes were analyzed based on tumor site using a 1:2 matched-control, as well as a multivariable Cox model. Results: Among 743 patients, 80 (10.7%) patients were diagnosed with GCA. Patients with GCA were more likely to have intestinal tumor type (GCA: 80.4% versus non-cardia: 64.2%, P=0.04) or advanced AJCC T stage tumors (GCA 71.8% versus non-cardia 59.2%, P=0.03). GCA patients more likely underwent a total gastrectomy (GCA: 85.7% vs. non-cardia: 39.8%) and had a longer length-of-stay (GCA: 10 days vs. noncardia: 8 days) (both P

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Clinicopathological features and prognosis of gastric cardia adenocarcinoma: A multi-institutional U.S. study

Abstract

Keywords

ASJC Scopus subject areas

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