Clinicopathological correlation of technetium bone scan in vascularization of hydroxyapatite implants: A primate model

Elba M. Pacheco, Ali Civelek, T. K. Natarajan, Sam A. D'Anna, Nicholas T. Iliff, W. Richard Green

Research output: Contribution to journalArticle

Abstract

Objectives: To report the histopathological and bone scan characteristics of the stages of hydroxyapatite fibrovascular integration and to consider the implications for the timing of peg drilling in a primate model. Design: Three monkeys received hydroxyapatite implants covered only anteriorly with a fascia lata button to which the rectus muscles were sutured. Weekly bone scans were evaluated quantitatively and qualitatively. The orbits were harvested at 2, 4, and 8 weeks and examined histopathologically. Results: Quantitatively, the implant's technetium uptake increased, then reached a plateau by 4 weeks. Peripheral uptake was present on the images and histologically at 2 weeks. When bone scan images suggested complete vascularization by the fourth week, the implant was 99% vascularized histologically. Completion of vascularization was ascertained at 8 weeks, without further discernible changes in the bone scans. Conclusions: The technetium bone scan is sensitive to the vascularization of the hydroxyapatite implant and discerns when complete vascularization is approached. This primate study models closely the clinical findings we have recently reported. We advocate at least a 4-week interval between the time the bone scan suggests full vascularization and peg drilling.

Original languageEnglish (US)
Pages (from-to)1173-1177
Number of pages5
JournalArchives of Ophthalmology
Volume115
Issue number9
StatePublished - 1997

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Technetium
Durapatite
Primates
Bone and Bones
Fascia Lata
Orbit
Haplorhini
Muscles

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Pacheco, E. M., Civelek, A., Natarajan, T. K., D'Anna, S. A., Iliff, N. T., & Richard Green, W. (1997). Clinicopathological correlation of technetium bone scan in vascularization of hydroxyapatite implants: A primate model. Archives of Ophthalmology, 115(9), 1173-1177.

Clinicopathological correlation of technetium bone scan in vascularization of hydroxyapatite implants : A primate model. / Pacheco, Elba M.; Civelek, Ali; Natarajan, T. K.; D'Anna, Sam A.; Iliff, Nicholas T.; Richard Green, W.

In: Archives of Ophthalmology, Vol. 115, No. 9, 1997, p. 1173-1177.

Research output: Contribution to journalArticle

Pacheco, EM, Civelek, A, Natarajan, TK, D'Anna, SA, Iliff, NT & Richard Green, W 1997, 'Clinicopathological correlation of technetium bone scan in vascularization of hydroxyapatite implants: A primate model', Archives of Ophthalmology, vol. 115, no. 9, pp. 1173-1177.
Pacheco EM, Civelek A, Natarajan TK, D'Anna SA, Iliff NT, Richard Green W. Clinicopathological correlation of technetium bone scan in vascularization of hydroxyapatite implants: A primate model. Archives of Ophthalmology. 1997;115(9):1173-1177.
Pacheco, Elba M. ; Civelek, Ali ; Natarajan, T. K. ; D'Anna, Sam A. ; Iliff, Nicholas T. ; Richard Green, W. / Clinicopathological correlation of technetium bone scan in vascularization of hydroxyapatite implants : A primate model. In: Archives of Ophthalmology. 1997 ; Vol. 115, No. 9. pp. 1173-1177.
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