Clinicopathologic Study of Blood-Retinal Barrier in Experimental Diabetes Mellitus

Mark O.M. Tso; Jose G. Cunha Vaz; Chi Yen Shih; Carl W. Jones

doi:10.1001/archopht.1980.01020040884020

Clinicopathologic Study of Blood-Retinal Barrier in Experimental Diabetes Mellitus

Mark O.M. Tso, Jose G. Cunha Vaz, Chi Yen Shih, Carl W. Jones

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89 Scopus citations

Abstract

Rats with experimental diabetes (induced by streptozocin [Streptozotocin]) were studied by vitreous fluorophotometry and horseradish peroxidase tracer technique. Vitreous fluorescein sodium concentration notably increased four to eight days after a single dose of streptozocin. No leakage from the retinal vasculature could be demonstrated by the horseradish peroxidase tracer study, but three types of retinal pigment epithelial (RPE) lesions were observed. The RPE lesions seemed to be partially responsible for the increase of vitreous fluorescein concentration.

Original language	English (US)
Pages (from-to)	2032-2040
Number of pages	9
Journal	Archives of ophthalmology
Volume	98
Issue number	11
DOIs	https://doi.org/10.1001/archopht.1980.01020040884020
State	Published - Nov 1980
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1980.01020040884020

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AB - Rats with experimental diabetes (induced by streptozocin [Streptozotocin]) were studied by vitreous fluorophotometry and horseradish peroxidase tracer technique. Vitreous fluorescein sodium concentration notably increased four to eight days after a single dose of streptozocin. No leakage from the retinal vasculature could be demonstrated by the horseradish peroxidase tracer study, but three types of retinal pigment epithelial (RPE) lesions were observed. The RPE lesions seemed to be partially responsible for the increase of vitreous fluorescein concentration.

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Clinicopathologic Study of Blood-Retinal Barrier in Experimental Diabetes Mellitus

Abstract

ASJC Scopus subject areas

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