Clinicopathologic correlations in the oligodendroglioma

Peter C. Burger, Charles E. Rawlings, Edwin B. Cox, Roger E. McLendon, S. Schold Clifford, Dennis E. Bullard

Research output: Contribution to journalArticle

Abstract

To determine the prognostic significance of histologic variables in oligodendroglial neoplasms, the presence and degree of 15 such variables were correlated with postoperative survival rates in 71 patients. By univariate analysis, prognostically significant factors, in order of decreasing importance, were mitoses (log), necrosis, nuclear cytologic atypia, vascular hypertrophy, and vascular proliferation. When studied by stepwise regression, necrosis and the number of mitoses contained all of the prognostically useful information. When each of the five variables significant by univariate analysis was tested in the Cox model by adding a variable to the model containing the other four, necrosis was found to be the only independently significant variable. There were significant positive pairwise correlations between each of the five significant histologic variables except for cytologic atypia with necrosis. The only histologic variable with a significant association with older age was the number of mitoses. These results suggest that necrosis and, to a lesser extent, the mitotic count are features that, in the appropriate setting, can be used to identify the “anaplastic” oligodendroglioma.

Original languageEnglish (US)
Pages (from-to)1345-1352
Number of pages8
JournalCancer
Volume59
Issue number7
DOIs
StatePublished - Apr 1 1987

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Burger, P. C., Rawlings, C. E., Cox, E. B., McLendon, R. E., Clifford, S. S., & Bullard, D. E. (1987). Clinicopathologic correlations in the oligodendroglioma. Cancer, 59(7), 1345-1352. https://doi.org/10.1002/1097-0142(19870401)59:7<1345::AID-CNCR2820590719>3.0.CO;2-A