Clinicopathologic correlation of lipidization and detachment of the retinal pigment epithelium

Fadi El Baba, W. Richard Green, Jay Fleischmann, Daniel Finkelstein, Zenaida C. de la Cruz

Research output: Contribution to journalArticle


A 49-year-old woman had a few small drusen-like lesions and one larger area of depigmentation in the right fundus. The pinpoint lesions corresponded to single enlarged retinal pigment epithelial cells with lipid accumulation and the larger area represented a small, localized retinal pigment epithelial detachment (soft druse). Lipoidal degeneration of individual retinal pigment epithelial cells may be a mechanism of nodular drusen formation. The soft druse was associated with thickening of the basement membrane of the retinal pigment epithelium.

Original languageEnglish (US)
Pages (from-to)576-583
Number of pages8
JournalAmerican Journal of Ophthalmology
Issue number5
StatePublished - May 15 1986


ASJC Scopus subject areas

  • Ophthalmology

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