Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma

Kenneth Aldape, Peter C. Burger, Arie Perry

Research output: Contribution to journalArticle

Abstract

Context. - Significant interobserver variability exists with respect to the diagnosis of oligodendroglial neoplasms, especially their distinction from astrocytoma and mixed oligoastrocytoma. Combined loss of the short arm of chromosome 1 and the long arm of chromosome 19 has been shown to be both relatively specific to oligodendroglioma and, when present, a marker of improved prognosis in patients with these tumors. In addition, 1p/19q loss has been shown to be a marker of "classic" oligodendroglial histology. These findings raise questions as to the role of 1p/19q testing in clinical practice, both as a prognostic marker and as a potential diagnostic marker among infiltrating glial neoplasms. Objective. - This review discusses the issues raised above and tries to clarify the current status of 1p/19q evaluation in the diagnosis of oligodendroglioma. Data Sources. - Sources for this review include recent literature as well as the experience of 3 practicing neuropathologists. Conclusions. - 1p/19q status is an important marker in oligodendroglioma. Loss of 1p/19q is associated with classic oligodendroglioma histology as well as improved prognosis. The combined 1p/19q marker will continue to be a clinically useful marker of prognosis and could potentially be incorporated into diagnostic criteria in the future.

Original languageEnglish (US)
Pages (from-to)242-251
Number of pages10
JournalArchives of Pathology and Laboratory Medicine
Volume131
Issue number2
StatePublished - Feb 2007

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Oligodendroglioma
Astrocytoma
Histology
Chromosomes, Human, Pair 19
Neoplasms
Observer Variation
Chromosomes, Human, Pair 1
Information Storage and Retrieval
Neuroglia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma. / Aldape, Kenneth; Burger, Peter C.; Perry, Arie.

In: Archives of Pathology and Laboratory Medicine, Vol. 131, No. 2, 02.2007, p. 242-251.

Research output: Contribution to journalArticle

Aldape, Kenneth ; Burger, Peter C. ; Perry, Arie. / Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma. In: Archives of Pathology and Laboratory Medicine. 2007 ; Vol. 131, No. 2. pp. 242-251.
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