Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon

Baojin Fu, Shinichi Yachida, Richard Morgan, Yi Zhong, Elizabeth A Montgomery, Christine A. Iacobuzio-Donahue

Research output: Contribution to journalArticle

Abstract

Traditional serrated adenomas (TSAs) are a type of colorectal polyp with neoplastic potential. Immunohistochemical analysis and sequencing were performed on 24 TSAs from 23 patients to characterize the molecular genetics of TSAs. Abnormal Ki-67 and p53 labeling were observed in 7 (29%) of 24 and 6 (25%) of 24 TSAs, respectively; both types were significantly associated with the presence of conventional epithelial dysplasia (P = .0005 and P = .0001, respectively). Activating KRAS mutation was identified in 11 TSAs (46%) and was mutually exclusive with activating BRAF mutations, which were seen in 7 TSAs (29%). Abnormal p53 nuclear labeling in a TSA was significantly associated with BRAF mutation status (P = .04), whereas no relationship was found for β-catenin labeling patterns. The overall morphologic features of TSA do not correlate with the genetic status of the KRAS and BRAF genes. However, conventional epithelial dysplasia and abnormal p53 labeling in a TSA are seen more often in the setting of BRAF mutation. Copyright

Original languageEnglish (US)
Pages (from-to)356-366
Number of pages11
JournalAmerican Journal of Clinical Pathology
Volume138
Issue number3
DOIs
Publication statusPublished - Sep 2012

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Keywords

  • BRAF
  • Colon polyp
  • KRAS
  • p53
  • Traditional serrated adenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon. / Fu, Baojin; Yachida, Shinichi; Morgan, Richard; Zhong, Yi; Montgomery, Elizabeth A; Iacobuzio-Donahue, Christine A.

In: American Journal of Clinical Pathology, Vol. 138, No. 3, 09.2012, p. 356-366.

Research output: Contribution to journalArticle