Clinicopathologic Analysis of Chondroblastoma in Adults: A Single-Institution Case Series

Stefano Negri, Sintawat Wangsiricharoen, Leslie Chang, John Gross, Adam S. Levin, Carol D. Morris, Edward F. McCarthy, Aaron W. James

Research output: Contribution to journalArticlepeer-review


Chondroblastoma is a rare benign tumor of immature cartilage cells that generally occurs in an epiphyseal location of skeletally immature individuals. However, a few studies have reported cases in older patients. The purpose of this study was to evaluate the clinical, radiographic, and pathologic features of chondroblastoma in an adult population. The pathology archives of our institution were searched for cases of chondroblastoma diagnosed in patients ≥25 years of age. Of 14 patients identified, 8 were male and 6 were female with a median age of 34 years (range = 29-54 years). Most lesions occurred in short bones of hands and feet (N = 7, 50%), followed by the long tubular bones (N = 4, 28%). All demonstrated typical histologic features of chondroblastoma, but more extensive calcification, necrosis, and degenerative changes were also seen. At follow-up (median = 73.5 months), 2 patients (17%) had local recurrence. None had metastasis. In summary, chondroblastoma in adults tends to involve the short bones of the hands and feet and demonstrate histologic changes associated with long-standing growth of a benign tumor.

Original languageEnglish (US)
Pages (from-to)120-128
Number of pages9
JournalInternational journal of surgical pathology
Issue number2
StatePublished - Apr 2021


  • benign bone tumors
  • chondroblastoma
  • histopathology
  • orthopedic oncology

ASJC Scopus subject areas

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine


Dive into the research topics of 'Clinicopathologic Analysis of Chondroblastoma in Adults: A Single-Institution Case Series'. Together they form a unique fingerprint.

Cite this