Clinico-pathologic features, treatment and outcomes of breast cancer during pregnancy or the post-partum period

Ciara C. O’Sullivan, Sheeba Irshad, Zheyu Wang, Zhuojun Tang, Christopher Umbricht, Gary L. Rosner, Mindy S. Christianson, Vered Stearns, Karen Lisa Smith

Research output: Contribution to journalArticle

Abstract

Purpose: Breast cancer during pregnancy (BC-P) or the first year post-partum (BC-PP) is rare and whether it differs from breast cancer (BC) in young women not associated with pregnancy is uncertain. Methods: We queried our institutional database for BC-P and BC-PP cases and matched controls with BC not associated with pregnancy diagnosed between January 1, 1985 and December 31, 2013. We performed two parallel retrospective cohort studies evaluating clinico-pathologic features, treatment and outcomes for BC-P and BC-PP cases compared to their controls. Results: In our population of 65 BC-P cases, 135 controls for BC-P cases, 75 BC-PP cases and 145 controls for BC-PP cases, high grade and estrogen receptor-negativity were more frequent in both case groups than their controls. Among those with stage I–III BC, patterns of local therapy were similar for both case groups and their controls, with the majority undergoing surgery and radiation. Over three-fourths of those with stage I–III BC received chemotherapy. BC-P cases tolerated chemotherapy well, with the majority receiving doxorubicin/cyclophosphamide every 3 weeks. On multivariate analyses of those with stage I–III BC, BC-P cases had non-significantly higher hazards of recurrence and death compared to their controls, while BC-PP cases had non-significantly lower hazards of recurrence and death compared to their controls. Conclusion: BC-P and BC-PP were associated with adverse clinic-pathologic features in our population. However, we did not observe inferior outcomes for BC-P or BC-PP compared to controls, likely due to receipt of aggressive multi-modality therapy.

Original languageEnglish (US)
Pages (from-to)695-706
Number of pages12
JournalBreast Cancer Research and Treatment
Volume180
Issue number3
DOIs
StatePublished - Apr 1 2020

Keywords

  • Breast cancer
  • Post-partum
  • Pregnancy
  • Prognosis
  • Young women

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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