Clinically Relevant Changes in Emotional Expression in Children With ADHD Treated With Lisdexamfetamine Dimesylate

Alain Katic, Lawrence Ginsberg, Rakesh Jain, Ben Adeyi, Bryan Dirks, Thomas Babcock, Brian Scheckner, Cynthia Richards, Robert Lasser, Atilla Turgay, Robert L. Findling

Research output: Contribution to journalArticlepeer-review


Objective: To describe clinically relevant effects of lisdexamfetamine dimesylate (LDX) on emotional expression (EE) in children with ADHD. Method: Children with ADHD participated in a 7-week, open-label, LDX dose-optimization study. Expression and Emotion Scale for Children (EESC) change scores were analyzed post hoc using two methods to determine proportion of participants with different categories of clinical response based on (a) clinically significant (movement >2 SD from baseline mean)/reliable change (not due to measurement error) and (b) standard error of measurement (SEM) as a measure of clinically meaningful change. Results: With LDX, no participants showed clinically significant/reliable improvement; 0.7% showed clinically significant/reliable deterioration of EE by reliable change index and movement from baseline mean. One third of participants had improved EE by SEM criteria; 9.2% had categorical worsening. Conclusion: Using clinically meaningful change and clinically significant/reliable change categories derived from the EESC, most participants had no worsening of EE with LDX.

Original languageEnglish (US)
Pages (from-to)384-397
Number of pages14
JournalJournal of Attention Disorders
Issue number5
StatePublished - Jul 2012
Externally publishedYes


  • ADHD
  • LDX
  • Lisdexamfetamine dimesylate
  • emotional lability
  • stimulant

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology


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