Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine - Enhancing magnetic resonance imaging lesions

M. E. Smith, L. A. Stone, P. S. Albert, J. A. Frank, R. Martin, M. Armstrong, H. Maloni, D. E. McFarlin, H. F. McFarland

Research output: Contribution to journalArticlepeer-review

Abstract

It is now well established that clinically stable patients with relapsing-remitting multiple sclerosis have ongoing disease activity when evaluated by serial gadolinium-enhanced (Gd-DTPA) magnetic resonance imaging (MRI) scans. Despite this, the relationship between clinical disease and MRI lesions, though suspected, has not been extensively documented. The relationship between Gd-DTPA MRI lesions and clinical disease was examined in this study of 9 patients with mild relapsing-remitting multiple sclerosis (Expanded Disability Status Scale [EDSS]

Original languageEnglish (US)
Pages (from-to)480-489
Number of pages10
JournalAnnals of Neurology
Volume33
Issue number5
StatePublished - May 1993
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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