Clinical versus rapid molecular HIV diagnosis in hospitalized african infants

A randomized controlled trial simulating point-of-care infant testing

Eric McCollum, Geoffrey A. Preidis, Madalitso Maliwichi, Dan Olson, L. Madeline McCrary, Peter N. Kazembe, Charles Van Der Horst, Irving Hoffman, Mina C. Hosseinipour

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Many African infants fail to receive their diagnostic HIV molecular test results and subsequently, antiretroviral therapy (ART). To determine whether a point-of-care molecular HIV test increases ART access for hospitalized Malawian infants, we simulated a point-of-care test using rapid HIV RNA polymerase chain reaction (Rapid PCR) and compared patient outcomes with an optimized standard care that included assessment with the World Health Organization clinical algorithm for HIV infection plus a DNA PCR with a turnaround time of several weeks (standard care). DESIGN: Randomized controlled trial. METHODS: Hospitalized HIV-exposed Malawian infants aged

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes
Volume66
Issue number1
DOIs
StatePublished - May 1 2014

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Randomized Controlled Trials
Point-of-Care Systems
HIV
Polymerase Chain Reaction
Molecular Pathology
DNA-Directed RNA Polymerases
HIV Infections
Point-of-Care Testing
DNA
Therapeutics

Keywords

  • Africa
  • DNA PCR
  • early infant diagnosis of HIV
  • point-of-care
  • presumptive diagnosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Clinical versus rapid molecular HIV diagnosis in hospitalized african infants : A randomized controlled trial simulating point-of-care infant testing. / McCollum, Eric; Preidis, Geoffrey A.; Maliwichi, Madalitso; Olson, Dan; McCrary, L. Madeline; Kazembe, Peter N.; Horst, Charles Van Der; Hoffman, Irving; Hosseinipour, Mina C.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 66, No. 1, 01.05.2014.

Research output: Contribution to journalArticle

McCollum, Eric ; Preidis, Geoffrey A. ; Maliwichi, Madalitso ; Olson, Dan ; McCrary, L. Madeline ; Kazembe, Peter N. ; Horst, Charles Van Der ; Hoffman, Irving ; Hosseinipour, Mina C. / Clinical versus rapid molecular HIV diagnosis in hospitalized african infants : A randomized controlled trial simulating point-of-care infant testing. In: Journal of Acquired Immune Deficiency Syndromes. 2014 ; Vol. 66, No. 1.
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