Clinical value of lung uptake of iodine-123 metaiodobenzylguanidine (MIBG), a myocardial sympathetic nerve imaging agent, in patients with chronic heart failure

Xiuli Mu; Shinji Hasegawa; Jun Yoshioka; Atsushi Maruyama; Kaoru Maruyama; Asit K. Paul; Hitoshi Yamaguchi; Takakazu Morozumi; Katsuji Hashimoto; Hideo Kusuoka; Tsunehiko Nishimura

doi:10.1007/BF02988344

Clinical value of lung uptake of iodine-123 metaiodobenzylguanidine (MIBG), a myocardial sympathetic nerve imaging agent, in patients with chronic heart failure

Xiuli Mu, Shinji Hasegawa, Jun Yoshioka, Atsushi Maruyama, Kaoru Maruyama, Asit K. Paul, Hitoshi Yamaguchi, Takakazu Morozumi, Katsuji Hashimoto, Hideo Kusuoka, Tsunehiko Nishimura

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

This study investigated the clinical value of I-123 MIBG pulmonary accumulation and washout in patients with chronic heart failure (CHF). Nineteen patients with CHF and 15 normal volunteers (NL) were included. The uptake ratio of heart to mediastinum (H/M), that of lung fields to mediastinum (L/M), and washout rate (WR) of the heart and lung fields were calculated in anterior planar images and compared with results of echocardiography and cardiac catheterization. In the CHF group, the lung uptake in delayed images increased and lung WR was decreased, suggesting pulmonary endothelial lesions. Furthermore, there was a negative correlation between right and left lung WR and pulmonary arterial diastolic pressure (PA(D)) and pulmonary arterial systolic pressure (PA(s)) in the CHF group. Since the WR of MIBG reflected PA, it may be used as an index of severity of cardiac dysfunction.

Original language	English (US)
Pages (from-to)	411-416
Number of pages	6
Journal	Annals of Nuclear Medicine
Volume	15
Issue number	5
DOIs	https://doi.org/10.1007/BF02988344
State	Published - 2001

Keywords

Chronic heart failure
Iodine-123 MIBG
Lung uptake

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/BF02988344

Cite this

Mu, X., Hasegawa, S., Yoshioka, J., Maruyama, A., Maruyama, K., Paul, A. K., Yamaguchi, H., Morozumi, T., Hashimoto, K., Kusuoka, H., & Nishimura, T. (2001). Clinical value of lung uptake of iodine-123 metaiodobenzylguanidine (MIBG), a myocardial sympathetic nerve imaging agent, in patients with chronic heart failure. Annals of Nuclear Medicine, 15(5), 411-416. https://doi.org/10.1007/BF02988344

Mu, X, Hasegawa, S, Yoshioka, J, Maruyama, A, Maruyama, K, Paul, AK, Yamaguchi, H, Morozumi, T, Hashimoto, K, Kusuoka, H & Nishimura, T 2001, 'Clinical value of lung uptake of iodine-123 metaiodobenzylguanidine (MIBG), a myocardial sympathetic nerve imaging agent, in patients with chronic heart failure', Annals of Nuclear Medicine, vol. 15, no. 5, pp. 411-416. https://doi.org/10.1007/BF02988344

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title = "Clinical value of lung uptake of iodine-123 metaiodobenzylguanidine (MIBG), a myocardial sympathetic nerve imaging agent, in patients with chronic heart failure",

abstract = "This study investigated the clinical value of I-123 MIBG pulmonary accumulation and washout in patients with chronic heart failure (CHF). Nineteen patients with CHF and 15 normal volunteers (NL) were included. The uptake ratio of heart to mediastinum (H/M), that of lung fields to mediastinum (L/M), and washout rate (WR) of the heart and lung fields were calculated in anterior planar images and compared with results of echocardiography and cardiac catheterization. In the CHF group, the lung uptake in delayed images increased and lung WR was decreased, suggesting pulmonary endothelial lesions. Furthermore, there was a negative correlation between right and left lung WR and pulmonary arterial diastolic pressure (PA(D)) and pulmonary arterial systolic pressure (PA(s)) in the CHF group. Since the WR of MIBG reflected PA, it may be used as an index of severity of cardiac dysfunction.",

keywords = "Chronic heart failure, Iodine-123 MIBG, Lung uptake",

author = "Xiuli Mu and Shinji Hasegawa and Jun Yoshioka and Atsushi Maruyama and Kaoru Maruyama and Paul, {Asit K.} and Hitoshi Yamaguchi and Takakazu Morozumi and Katsuji Hashimoto and Hideo Kusuoka and Tsunehiko Nishimura",

note = "Funding Information: A part of the study was supported by Takatsuki Rotary Club (to XM).",

year = "2001",

doi = "10.1007/BF02988344",

language = "English (US)",

volume = "15",

pages = "411--416",

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AU - Mu, Xiuli

AU - Hasegawa, Shinji

AU - Yoshioka, Jun

AU - Maruyama, Atsushi

AU - Maruyama, Kaoru

AU - Paul, Asit K.

AU - Yamaguchi, Hitoshi

AU - Morozumi, Takakazu

AU - Hashimoto, Katsuji

AU - Kusuoka, Hideo

AU - Nishimura, Tsunehiko

N1 - Funding Information: A part of the study was supported by Takatsuki Rotary Club (to XM).

PY - 2001

Y1 - 2001

N2 - This study investigated the clinical value of I-123 MIBG pulmonary accumulation and washout in patients with chronic heart failure (CHF). Nineteen patients with CHF and 15 normal volunteers (NL) were included. The uptake ratio of heart to mediastinum (H/M), that of lung fields to mediastinum (L/M), and washout rate (WR) of the heart and lung fields were calculated in anterior planar images and compared with results of echocardiography and cardiac catheterization. In the CHF group, the lung uptake in delayed images increased and lung WR was decreased, suggesting pulmonary endothelial lesions. Furthermore, there was a negative correlation between right and left lung WR and pulmonary arterial diastolic pressure (PA(D)) and pulmonary arterial systolic pressure (PA(s)) in the CHF group. Since the WR of MIBG reflected PA, it may be used as an index of severity of cardiac dysfunction.

AB - This study investigated the clinical value of I-123 MIBG pulmonary accumulation and washout in patients with chronic heart failure (CHF). Nineteen patients with CHF and 15 normal volunteers (NL) were included. The uptake ratio of heart to mediastinum (H/M), that of lung fields to mediastinum (L/M), and washout rate (WR) of the heart and lung fields were calculated in anterior planar images and compared with results of echocardiography and cardiac catheterization. In the CHF group, the lung uptake in delayed images increased and lung WR was decreased, suggesting pulmonary endothelial lesions. Furthermore, there was a negative correlation between right and left lung WR and pulmonary arterial diastolic pressure (PA(D)) and pulmonary arterial systolic pressure (PA(s)) in the CHF group. Since the WR of MIBG reflected PA, it may be used as an index of severity of cardiac dysfunction.

KW - Chronic heart failure

KW - Iodine-123 MIBG

KW - Lung uptake

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Clinical value of lung uptake of iodine-123 metaiodobenzylguanidine (MIBG), a myocardial sympathetic nerve imaging agent, in patients with chronic heart failure

Abstract

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