Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer

Adam Sharp, Jon C. Welti, Maryou B.K. Lambros, David Dolling, Daniel Nava Rodrigues, Lorna Pope, Caterina Aversa, Ines Figueiredo, Jennifer Fraser, Zai Ahmad, Changxue Lu, Pasquale Rescigno, Michael Kolinsky, Claudia Bertan, George Seed, Ruth Riisnaes, Susana Miranda, Mateus Crespo, Rita Pereira, Ana Ferreira & 15 others Gemma Fowler, Berni Ebbs, Penny Flohr, Antje Neeb, Diletta Bianchini, Antonella Petremolo, Semini Sumanasuriya, Alec Paschalis, Joaquin Mateo, Nina Tunariu, Wei Yuan, Suzanne Carreira, Stephen R. Plymate, Jun Luo, Johann S. de Bono

Research output: Contribution to journalArticle

Abstract

Liquid biopsies that identify androgen receptor splice variant-7 positivity, which account for circulating tumour cell counts, could inform treatment decisions in metastatic castration-resistant prostate cancer patients.

Original languageEnglish (US)
JournalEuropean Urology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Circulating Neoplastic Cells
Castration
Androgen Receptors
Prostatic Neoplasms
Cell Count
Biopsy
Therapeutics

Keywords

  • Androgen receptor
  • Androgen receptor splice variant-7
  • Biomarker
  • Liquid biopsy
  • Metastatic castration-resistant prostate cancer
  • Prognostic

ASJC Scopus subject areas

  • Urology

Cite this

Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer. / Sharp, Adam; Welti, Jon C.; Lambros, Maryou B.K.; Dolling, David; Rodrigues, Daniel Nava; Pope, Lorna; Aversa, Caterina; Figueiredo, Ines; Fraser, Jennifer; Ahmad, Zai; Lu, Changxue; Rescigno, Pasquale; Kolinsky, Michael; Bertan, Claudia; Seed, George; Riisnaes, Ruth; Miranda, Susana; Crespo, Mateus; Pereira, Rita; Ferreira, Ana; Fowler, Gemma; Ebbs, Berni; Flohr, Penny; Neeb, Antje; Bianchini, Diletta; Petremolo, Antonella; Sumanasuriya, Semini; Paschalis, Alec; Mateo, Joaquin; Tunariu, Nina; Yuan, Wei; Carreira, Suzanne; Plymate, Stephen R.; Luo, Jun; de Bono, Johann S.

In: European Urology, 01.01.2019.

Research output: Contribution to journalArticle

Sharp, A, Welti, JC, Lambros, MBK, Dolling, D, Rodrigues, DN, Pope, L, Aversa, C, Figueiredo, I, Fraser, J, Ahmad, Z, Lu, C, Rescigno, P, Kolinsky, M, Bertan, C, Seed, G, Riisnaes, R, Miranda, S, Crespo, M, Pereira, R, Ferreira, A, Fowler, G, Ebbs, B, Flohr, P, Neeb, A, Bianchini, D, Petremolo, A, Sumanasuriya, S, Paschalis, A, Mateo, J, Tunariu, N, Yuan, W, Carreira, S, Plymate, SR, Luo, J & de Bono, JS 2019, 'Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer', European Urology. https://doi.org/10.1016/j.eururo.2019.04.006
Sharp, Adam ; Welti, Jon C. ; Lambros, Maryou B.K. ; Dolling, David ; Rodrigues, Daniel Nava ; Pope, Lorna ; Aversa, Caterina ; Figueiredo, Ines ; Fraser, Jennifer ; Ahmad, Zai ; Lu, Changxue ; Rescigno, Pasquale ; Kolinsky, Michael ; Bertan, Claudia ; Seed, George ; Riisnaes, Ruth ; Miranda, Susana ; Crespo, Mateus ; Pereira, Rita ; Ferreira, Ana ; Fowler, Gemma ; Ebbs, Berni ; Flohr, Penny ; Neeb, Antje ; Bianchini, Diletta ; Petremolo, Antonella ; Sumanasuriya, Semini ; Paschalis, Alec ; Mateo, Joaquin ; Tunariu, Nina ; Yuan, Wei ; Carreira, Suzanne ; Plymate, Stephen R. ; Luo, Jun ; de Bono, Johann S. / Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer. In: European Urology. 2019.
@article{263e9f0a59094545b6f1035ae23e0c7c,
title = "Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer",
abstract = "Liquid biopsies that identify androgen receptor splice variant-7 positivity, which account for circulating tumour cell counts, could inform treatment decisions in metastatic castration-resistant prostate cancer patients.",
keywords = "Androgen receptor, Androgen receptor splice variant-7, Biomarker, Liquid biopsy, Metastatic castration-resistant prostate cancer, Prognostic",
author = "Adam Sharp and Welti, {Jon C.} and Lambros, {Maryou B.K.} and David Dolling and Rodrigues, {Daniel Nava} and Lorna Pope and Caterina Aversa and Ines Figueiredo and Jennifer Fraser and Zai Ahmad and Changxue Lu and Pasquale Rescigno and Michael Kolinsky and Claudia Bertan and George Seed and Ruth Riisnaes and Susana Miranda and Mateus Crespo and Rita Pereira and Ana Ferreira and Gemma Fowler and Berni Ebbs and Penny Flohr and Antje Neeb and Diletta Bianchini and Antonella Petremolo and Semini Sumanasuriya and Alec Paschalis and Joaquin Mateo and Nina Tunariu and Wei Yuan and Suzanne Carreira and Plymate, {Stephen R.} and Jun Luo and {de Bono}, {Johann S.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.eururo.2019.04.006",
language = "English (US)",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",

}

TY - JOUR

T1 - Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer

AU - Sharp, Adam

AU - Welti, Jon C.

AU - Lambros, Maryou B.K.

AU - Dolling, David

AU - Rodrigues, Daniel Nava

AU - Pope, Lorna

AU - Aversa, Caterina

AU - Figueiredo, Ines

AU - Fraser, Jennifer

AU - Ahmad, Zai

AU - Lu, Changxue

AU - Rescigno, Pasquale

AU - Kolinsky, Michael

AU - Bertan, Claudia

AU - Seed, George

AU - Riisnaes, Ruth

AU - Miranda, Susana

AU - Crespo, Mateus

AU - Pereira, Rita

AU - Ferreira, Ana

AU - Fowler, Gemma

AU - Ebbs, Berni

AU - Flohr, Penny

AU - Neeb, Antje

AU - Bianchini, Diletta

AU - Petremolo, Antonella

AU - Sumanasuriya, Semini

AU - Paschalis, Alec

AU - Mateo, Joaquin

AU - Tunariu, Nina

AU - Yuan, Wei

AU - Carreira, Suzanne

AU - Plymate, Stephen R.

AU - Luo, Jun

AU - de Bono, Johann S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Liquid biopsies that identify androgen receptor splice variant-7 positivity, which account for circulating tumour cell counts, could inform treatment decisions in metastatic castration-resistant prostate cancer patients.

AB - Liquid biopsies that identify androgen receptor splice variant-7 positivity, which account for circulating tumour cell counts, could inform treatment decisions in metastatic castration-resistant prostate cancer patients.

KW - Androgen receptor

KW - Androgen receptor splice variant-7

KW - Biomarker

KW - Liquid biopsy

KW - Metastatic castration-resistant prostate cancer

KW - Prognostic

UR - http://www.scopus.com/inward/record.url?scp=85064743531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064743531&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2019.04.006

DO - 10.1016/j.eururo.2019.04.006

M3 - Article

JO - European Urology

JF - European Urology

SN - 0302-2838

ER -