Abstract
Purpose of review: This review will focus on recent developments in biomarkers of myocardial injury. We will discuss the clinical utility of cardiac-specific troponin in the post-operative setting and highlight some of the most promising new biomarkers under development. Recent findings: Troponin I and T, measured in the post-operative setting, have been recently shown to have strong short- and long-term prognostic information in cardiac and vascular surgery patients. This ability of troponins to risk stratify post-operative patients occurs independent of clinical factors and other biomarkers. Additionally, brain natriuretic peptide has garnered significant interest as a biomarker of neurohormonal activation and appears to yield independent prognostic information from troponins. Recent studies have introduced two new biomarkers, soluble CD40 ligand and ischemia-modified albumin, which may aid in both diagnostic and prognostic decision making. Summary The current data strongly supports the use of troponin I and T in post-operative non-cardiac and cardiac surgical patients to assist in identifying those patients at high risk for short- and long-term complications. Several promising new biomarkers are currently under development but further studies are warranted to define their role in the post-operative setting.
Original language | English (US) |
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Pages (from-to) | 49-55 |
Number of pages | 7 |
Journal | Current Opinion in Anaesthesiology |
Volume | 17 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2004 |
Externally published | Yes |
Keywords
- Biomarkers
- Cardiac-specific troponin
- Ischemia-modified albumin
- Myocardial injury
- Soluble CD40 ligand
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine