Clinical utility of biomarkers in myocardial injury

Michael Y. Chan, Peter J. Pronovost

Research output: Contribution to journalReview article

Abstract

Purpose of review: This review will focus on recent developments in biomarkers of myocardial injury. We will discuss the clinical utility of cardiac-specific troponin in the post-operative setting and highlight some of the most promising new biomarkers under development. Recent findings: Troponin I and T, measured in the post-operative setting, have been recently shown to have strong short- and long-term prognostic information in cardiac and vascular surgery patients. This ability of troponins to risk stratify post-operative patients occurs independent of clinical factors and other biomarkers. Additionally, brain natriuretic peptide has garnered significant interest as a biomarker of neurohormonal activation and appears to yield independent prognostic information from troponins. Recent studies have introduced two new biomarkers, soluble CD40 ligand and ischemia-modified albumin, which may aid in both diagnostic and prognostic decision making. Summary The current data strongly supports the use of troponin I and T in post-operative non-cardiac and cardiac surgical patients to assist in identifying those patients at high risk for short- and long-term complications. Several promising new biomarkers are currently under development but further studies are warranted to define their role in the post-operative setting.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalCurrent Opinion in Anaesthesiology
Volume17
Issue number1
DOIs
StatePublished - Feb 1 2004

Keywords

  • Biomarkers
  • Cardiac-specific troponin
  • Ischemia-modified albumin
  • Myocardial injury
  • Soluble CD40 ligand

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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