Clinical utility of available methods for determining platelet function

Marcus E. McKenzie, Paul A. Gurbel, Douglas J. Levine, Victor L. Serebruany

Research output: Contribution to journalReview articlepeer-review

Abstract

Determination of platelet function has become increasingly important as new antiplatelet drugs are being developed. Objective means to monitor the pharmacological effects of these agents, in order to maximize efficacy and minimize toxicity, is needed. The available methods for determination of platelet function at the current time are reviewed, including platelet aggregometry, the PFA-100, flow cytometry, platelet contractile force, the rapid platelet function assay, the clot signature analyzer, Sonoclot, and thromboelastography. The principle, advantages, disadvantages, and clinical utility of each method is presented. The uses of the various methods of determining platelet function reported in the literature are summarized, in an effort to provide information regarding the applicability of those different methods. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)240-247
Number of pages8
JournalCardiology
Volume92
Issue number4
DOIs
StatePublished - Jan 1 1999

Keywords

  • Analyzers
  • Clinical utility
  • Platelet function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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