Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma

Russell Maxwell, Christopher M. Jackson, Michael Lim

Research output: Contribution to journalReview articlepeer-review

Abstract

Immune checkpoint inhibitors have changed the landscape of cancer immunotherapy and are being integrated into the standard of care for a variety of solid and hematologic malignancies. Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and carries a grave prognosis despite advances in surgical resection, chemotherapy, and radiation therapy. Implementing immunotherapy for brain tumors mandates additional considerations due to the unique structural and immunologic milieu of the central nervous system (CNS). Nevertheless, strong data from preclinical studies have driven clinical trials of immune checkpoint blockade for newly diagnosed and recurrent GBM. The focus of this review is to discuss the ongoing clinical trials of checkpoint inhibitors in GBM and review the immunologic rationale for ongoing and future trial designs.

Original languageEnglish (US)
Article number51
JournalCurrent Treatment Options in Oncology
Volume18
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • CTLA-4
  • Glioblastoma
  • Immune checkpoint
  • Malignant glioma
  • PD-1
  • PD-L1

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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