TY - JOUR
T1 - Clinical transplantation tolerance
T2 - Many rivers to cross
AU - Salama, Alan D.
AU - Womer, Karl L.
AU - Sayegh, Mohamed H.
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Modern immunosuppressive regimens for organ transplantation have resulted in excellent short-term results but less dramatic improvements in long-term outcomes. Moreover, they are associated with significant deleterious effects. One solution that should avoid the adverse drug effects and result in improved graft and patient longevity as well as positively impacting on the organ shortage is the establishment of transplantation tolerance. Ever since the original description of transplantation tolerance in rodent allografts, there have been significant efforts made to translate tolerance-promoting strategies to the clinical arena. However, > 50 years later, we are still faced with significant barriers that are preventing such a goal from being widely attained. Nonetheless, pilot clinical tolerance protocols are underway in selected transplant recipients. In this review, we discuss the scientific and nonscientific issues that must be overcome for successful transplantation tolerance to become a clinical reality.
AB - Modern immunosuppressive regimens for organ transplantation have resulted in excellent short-term results but less dramatic improvements in long-term outcomes. Moreover, they are associated with significant deleterious effects. One solution that should avoid the adverse drug effects and result in improved graft and patient longevity as well as positively impacting on the organ shortage is the establishment of transplantation tolerance. Ever since the original description of transplantation tolerance in rodent allografts, there have been significant efforts made to translate tolerance-promoting strategies to the clinical arena. However, > 50 years later, we are still faced with significant barriers that are preventing such a goal from being widely attained. Nonetheless, pilot clinical tolerance protocols are underway in selected transplant recipients. In this review, we discuss the scientific and nonscientific issues that must be overcome for successful transplantation tolerance to become a clinical reality.
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U2 - 10.4049/jimmunol.178.9.5419
DO - 10.4049/jimmunol.178.9.5419
M3 - Short survey
C2 - 17442921
AN - SCOPUS:34247620262
SN - 0022-1767
VL - 178
SP - 5419
EP - 5423
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -