Clinical translation of epigenetics in cancer: eN-CORe - A report on the second workshop

Arthur Zelent, Kevin Petrie, Reuben Lotan, Samuel Waxman, Steven D. Gore

Research output: Contribution to journalArticle

Abstract

Recent advances in understanding the role that epigenetics plays in cancer pathogenesis and understanding the mechanisms through which these processes regulate gene expression have stimulated considerable interest in developing clinically viable antineoplastic agents that target enzymatic components of transcriptional regulatory complexes responsible for the establishment of pathologic epigenetic modifications that lead to deregulated gene expression in cancer. In January 2003, a workshop was held in Baltimore to discuss the therapeutic potential of several agents that can modify chromatin structure. A follow-up meeting on "Clinical Translation of Epigenetics in Cancer" was held in Charleston, SC, in January 2005. The aim of this workshop was to assess the progress that has been made over the past 2 years in bringing effective therapeutic protocols that use agents capable of reverting pathologic epigenetic changes into the clinic. The meeting was attended by ∼ 70 investigators and included formal presentations, panel group discussions, and two breakout sessions that addressed targeted therapies in hematologic and solid tumors. The aim of this article is to summarize topics discussed at this workshop and highlight conclusions as to the immediate and long-term future of epigenetic therapy in cancer.

Original languageEnglish (US)
Pages (from-to)1810-1819
Number of pages10
JournalMolecular Cancer Therapeutics
Volume4
Issue number11
DOIs
Publication statusPublished - Nov 2005

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ASJC Scopus subject areas

  • Oncology
  • Drug Discovery
  • Pharmacology

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