Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women

The power study

Giovanni Cizza, Donna S. Ronsaville, Hayley Kleitz, Farideh Eskandari, Sejal Mistry, Sara Torvik, Nina Sonbolian, James C. Reynolds, Marc R. Blackman, Philip W. Gold, Pedro E. Martinez

Research output: Contribution to journalArticle

Abstract

Background: Major depressive disorder (MDD) has been associated with adverse medical consequences, including cardiovascular disease and osteoporosis. Patients with MDD may be classified as having melancholic, atypical, or undifferentiated features. The goal of the present study was to assess whether these clinical subtypes of depression have different endocrine and metabolic features and consequently, varying medical outcomes. Methods: Premenopausal women, ages 21 to 45 years, with MDD (N = 89) and healthy controls (N = 44) were recruited for a prospective study of bone turnover. Women with MDD were classified as having melancholic (N = 51), atypical (N = 16), or undifferentiated (N = 22) features. Outcome measures included: metabolic parameters, body composition, bone mineral density (BMD), and 24 hourly sampling of plasma adrenocorticotropin (ACTH), cortisol, and leptin. Results: Compared with control subjects, women with undifferentiated and atypical features of MDD exhibited greater BMI, waist/hip ratio, and whole body and abdominal fat mass. Women with undifferentiated MDD characteristics also had higher lipid and fasting glucose levels in addition to a greater prevalence of low BMD at the femoral neck compared to controls. Elevated ACTH levels were demonstrated in women with atypical features of depression, whereas higher mean 24-hour leptin levels were observed in the melancholic subgroup. Conclusions: Pre-menopausal women with various features of MDD exhibit metabolic, endocrine, and BMD features that may be associated with different health consequences.

Original languageEnglish (US)
Article numbere28912
JournalPLoS One
Volume7
Issue number1
DOIs
StatePublished - Jan 3 2012
Externally publishedYes

Fingerprint

Major Depressive Disorder
Bone
Adrenocorticotropic Hormone
Depression
Minerals
bone density
corticotropin
Leptin
Bone Density
leptin
Hydrocortisone
menopause
waist
Fats
osteoporosis
Health
Abdominal Fat
abdominal fat
thighs
Sampling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cizza, G., Ronsaville, D. S., Kleitz, H., Eskandari, F., Mistry, S., Torvik, S., ... Martinez, P. E. (2012). Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: The power study. PLoS One, 7(1), [e28912]. https://doi.org/10.1371/journal.pone.0028912

Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women : The power study. / Cizza, Giovanni; Ronsaville, Donna S.; Kleitz, Hayley; Eskandari, Farideh; Mistry, Sejal; Torvik, Sara; Sonbolian, Nina; Reynolds, James C.; Blackman, Marc R.; Gold, Philip W.; Martinez, Pedro E.

In: PLoS One, Vol. 7, No. 1, e28912, 03.01.2012.

Research output: Contribution to journalArticle

Cizza, G, Ronsaville, DS, Kleitz, H, Eskandari, F, Mistry, S, Torvik, S, Sonbolian, N, Reynolds, JC, Blackman, MR, Gold, PW & Martinez, PE 2012, 'Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: The power study', PLoS One, vol. 7, no. 1, e28912. https://doi.org/10.1371/journal.pone.0028912
Cizza, Giovanni ; Ronsaville, Donna S. ; Kleitz, Hayley ; Eskandari, Farideh ; Mistry, Sejal ; Torvik, Sara ; Sonbolian, Nina ; Reynolds, James C. ; Blackman, Marc R. ; Gold, Philip W. ; Martinez, Pedro E. / Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women : The power study. In: PLoS One. 2012 ; Vol. 7, No. 1.
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