Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia

L. E. Tune, I. Creese, J. R. DePaulo, P. R. Slavney, J. T. Coyle, S. H. Snyder

Research output: Contribution to journalArticle

Abstract

The authors measured serum neuroleptic levels by radioreceptor assay in 30 schizophrenic patients receiving haloperidol, fluphenazine, chlorpromazine, molindone, thiothixene, or trifluoperazine. Neuroleptic levels were significantly correlated with clinical state, monitored by an abbreviated version of the Present State Examination (the mini-PSE). Poor therapeutic responses were associated with serum levels under 50 μg/ml chlorpromazine equivalents. There was no correlation between neuroleptic dosage and mini-PSE score or between neuroleptic dose and serum neuroleptic levels.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalAmerican Journal of Psychiatry
Volume137
Issue number2
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Psychiatry and Mental health

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