Clinical significance of neurocysticercosis in endemic villages

Hector H. García; Robert H. Gilman; Victor C.W. Tsang; Armando E. Gonzalez; M. Verastegui; M. P. Torres; E. Miranda; G. Herrera; C. Gavidia; E. Barron; N. Falcon; M. T. Lopez; M. Martinez; C. Evans; J. B. Pilcher

doi:10.1016/S0035-9203(97)90213-3

Clinical significance of neurocysticercosis in endemic villages

Hector H. García, Robert H. Gilman, Victor C.W. Tsang, Armando E. Gonzalez, M. Verastegui, M. P. Torres, E. Miranda, G. Herrera, C. Gavidia, E. Barron, N. Falcon, M. T. Lopez, M. Martinez, C. Evans, J. B. Pilcher

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Cerebral cysticercosis is the main cause of late-onset epilepsy in most developing countries. Data on the neuroepidemiology of cysticercosis in endemic populations is scarce. In an endemic village on the northern coast of Peru, 49 individuals with neurological symptomatology (41 epileptic and 8 non-epileptic) were screened for antibodies to Taenia solium, using a serum electroimmunotransfer blot assay. Fifteen subjects were seropositive, 14 (34%) of those with epilepsy but only one (13%) of those who were non-epileptic. A history of passing proglottides was associated with positive serology. Thirteen of the 15 seropositive individuals underwent cerebral computed tomography; only 7 (54%) were abnormal. A randomly selected sample of 20 pigs from the village was also tested, and 6 (30%) were seropositive. This study demonstrated the importance of cysticercosis in the aetiology of epilepsy in endemic villages and the close relationship between porcine and human infection.

Original language	English (US)
Pages (from-to)	176-178
Number of pages	3
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	91
Issue number	2
DOIs	https://doi.org/10.1016/S0035-9203(97)90213-3
State	Published - 1997

Keywords

Cysticercosis
Epilepsy
Peru
Taenia solium

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0035-9203(97)90213-3

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García, H. H., Gilman, R. H., Tsang, V. C. W., Gonzalez, A. E., Verastegui, M., Torres, M. P., Miranda, E., Herrera, G., Gavidia, C., Barron, E., Falcon, N., Lopez, M. T., Martinez, M., Evans, C., & Pilcher, J. B. (1997). Clinical significance of neurocysticercosis in endemic villages. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91(2), 176-178. https://doi.org/10.1016/S0035-9203(97)90213-3

García, HH, Gilman, RH, Tsang, VCW, Gonzalez, AE, Verastegui, M, Torres, MP, Miranda, E, Herrera, G, Gavidia, C, Barron, E, Falcon, N, Lopez, MT, Martinez, M, Evans, C & Pilcher, JB 1997, 'Clinical significance of neurocysticercosis in endemic villages', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 91, no. 2, pp. 176-178. https://doi.org/10.1016/S0035-9203(97)90213-3

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abstract = "Cerebral cysticercosis is the main cause of late-onset epilepsy in most developing countries. Data on the neuroepidemiology of cysticercosis in endemic populations is scarce. In an endemic village on the northern coast of Peru, 49 individuals with neurological symptomatology (41 epileptic and 8 non-epileptic) were screened for antibodies to Taenia solium, using a serum electroimmunotransfer blot assay. Fifteen subjects were seropositive, 14 (34%) of those with epilepsy but only one (13%) of those who were non-epileptic. A history of passing proglottides was associated with positive serology. Thirteen of the 15 seropositive individuals underwent cerebral computed tomography; only 7 (54%) were abnormal. A randomly selected sample of 20 pigs from the village was also tested, and 6 (30%) were seropositive. This study demonstrated the importance of cysticercosis in the aetiology of epilepsy in endemic villages and the close relationship between porcine and human infection.",

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author = "Garc{\'i}a, {Hector H.} and Gilman, {Robert H.} and Tsang, {Victor C.W.} and Gonzalez, {Armando E.} and M. Verastegui and Torres, {M. P.} and E. Miranda and G. Herrera and C. Gavidia and E. Barron and N. Falcon and Lopez, {M. T.} and M. Martinez and C. Evans and Pilcher, {J. B.}",

year = "1997",

doi = "10.1016/S0035-9203(97)90213-3",

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AU - Gilman, Robert H.

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AU - Torres, M. P.

AU - Miranda, E.

AU - Herrera, G.

AU - Gavidia, C.

AU - Barron, E.

AU - Falcon, N.

AU - Lopez, M. T.

AU - Martinez, M.

AU - Evans, C.

AU - Pilcher, J. B.

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N2 - Cerebral cysticercosis is the main cause of late-onset epilepsy in most developing countries. Data on the neuroepidemiology of cysticercosis in endemic populations is scarce. In an endemic village on the northern coast of Peru, 49 individuals with neurological symptomatology (41 epileptic and 8 non-epileptic) were screened for antibodies to Taenia solium, using a serum electroimmunotransfer blot assay. Fifteen subjects were seropositive, 14 (34%) of those with epilepsy but only one (13%) of those who were non-epileptic. A history of passing proglottides was associated with positive serology. Thirteen of the 15 seropositive individuals underwent cerebral computed tomography; only 7 (54%) were abnormal. A randomly selected sample of 20 pigs from the village was also tested, and 6 (30%) were seropositive. This study demonstrated the importance of cysticercosis in the aetiology of epilepsy in endemic villages and the close relationship between porcine and human infection.

AB - Cerebral cysticercosis is the main cause of late-onset epilepsy in most developing countries. Data on the neuroepidemiology of cysticercosis in endemic populations is scarce. In an endemic village on the northern coast of Peru, 49 individuals with neurological symptomatology (41 epileptic and 8 non-epileptic) were screened for antibodies to Taenia solium, using a serum electroimmunotransfer blot assay. Fifteen subjects were seropositive, 14 (34%) of those with epilepsy but only one (13%) of those who were non-epileptic. A history of passing proglottides was associated with positive serology. Thirteen of the 15 seropositive individuals underwent cerebral computed tomography; only 7 (54%) were abnormal. A randomly selected sample of 20 pigs from the village was also tested, and 6 (30%) were seropositive. This study demonstrated the importance of cysticercosis in the aetiology of epilepsy in endemic villages and the close relationship between porcine and human infection.

KW - Cysticercosis

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KW - Peru

KW - Taenia solium

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Clinical significance of neurocysticercosis in endemic villages

Abstract

Keywords

ASJC Scopus subject areas

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