Clinical Significance of Alloantibodies in Hand Transplantation: A Multicenter Study

Erik Berglund, Mette Andersen Ljungdahl, Darko Bogdanović, David Berglund, Jonas Wadström, Jan Kowalski, Gerald Brandacher, Dorota Kamińska, Christina L. Kaufman, Simon G. Talbot, Kodi Azari, Luis Landin, Christoph Höhnke, Karen M. Dwyer, Pedro C. Cavadas, Alessandro Thione, Brendan Clarke, Simon Kay, Dan Wilks, Subramania IyerMartin Iglesias, Ömer Özkan, Özlenen Özkan, Johanna Krapf, Annemarie Weissenbacher, Palmina Petruzzo, Stefan Schneeberger

Research output: Contribution to journalArticle

Abstract

Background. Donor-specific antibodies (DSAs) have a strong negative correlation with long-term survival in solid organ transplantation. Although the clinical significance of DSA and antibody-mediated rejection (AMR) in upper extremity transplantation (UET) remains to be established, a growing number of single-center reports indicate their presence and potential clinical impact. Methods. We present a multicenter study assessing the occurrence and significance of alloantibodies in UET in reference to immunological parameters and functional outcome. Results. Our study revealed a high prevalence and early development of de novo DSA and non-DSA (43%, the majority detected within the first 3 postoperative y). HLA class II mismatch correlated with antibody development, which in turn significantly correlated with the incidence of acute cellular rejection. Cellular rejections preceded antibody development in almost all cases. A strong correlation between DSA and graft survival or function cannot be statistically established at this early stage but a correlation with a lesser outcome seems to emerge. Conclusions. While the phenotype and true clinical effect of AMR remain to be better defined, the high prevalence of DSA and the correlation with acute rejection highlight the need for optimizing immunosuppression, close monitoring, and the relevance of an HLA class II match in UET recipients.

Original languageEnglish (US)
Pages (from-to)2173-2182
Number of pages10
JournalTransplantation
Volume103
Issue number10
DOIs
StatePublished - Oct 1 2019

ASJC Scopus subject areas

  • Transplantation

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    Berglund, E., Andersen Ljungdahl, M., Bogdanović, D., Berglund, D., Wadström, J., Kowalski, J., Brandacher, G., Kamińska, D., Kaufman, C. L., Talbot, S. G., Azari, K., Landin, L., Höhnke, C., Dwyer, K. M., Cavadas, P. C., Thione, A., Clarke, B., Kay, S., Wilks, D., ... Schneeberger, S. (2019). Clinical Significance of Alloantibodies in Hand Transplantation: A Multicenter Study. Transplantation, 103(10), 2173-2182. https://doi.org/10.1097/TP.0000000000002650