Clinical relevance of indoleamine 2,3-dioxygenase for alloimmunity and transplantation

Gerald Brandacher, Raimund Margreiter, Dietmar Fuchs

Research output: Contribution to journalReview articlepeer-review

Abstract

PURPOSE OF REVIEW: The immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) is activated by interferon-γ and via tryptophan depletion and the production of proapoptotic downstream metabolites IDO suppresses adaptive T-cell-mediated immunity in inflammation, host immune defence and maternal tolerance. In addition, IDO-mediated tryptophan catabolism occurring in dendritic cells is an emerging potent mechanism of peripheral tolerance. RECENT FINDINGS: Recent data dissecting the molecular T-cell regulatory mechanisms and immunomodulatory features of IDO have given rise to the development of new concepts for translating such naturally occurring tolerance mechanisms of IDO into the service of permanent graft acceptance, thereby eventually facilitating the ultimate goal in transplantation of donor antigen-specific unresponsiveness. SUMMARY: This review focuses on the nature and mechanisms of IDO-mediated immune regulation in alloimmunity and transplantation and outlines its clinical relevance and therapeutic implications.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalCurrent opinion in organ transplantation
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

Keywords

  • Immune regulation
  • Indoleamine 2,3-dioxygenase
  • Tolerance
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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