Clinical reactivations of herpes simplex virus type 2 infection and human immunodeficiency virus disease progression markers

Bulbulgul Aumakhan, Charlotte A Gaydos, Thomas C Quinn, Christopher Beyrer, Lorie Benning, Howard Minkoff, Daniel J. Merenstein, Mardge Cohen, Ruth Greenblatt, Marek Nowicki, Kathryn Anastos, Stephen J Gange

Research output: Contribution to journalArticle

Abstract

Background: The natural history of HSV-2 infection and role of HSV-2 reactivations in HIV disease progression are unclear. Methods: Clinical symptoms of active HSV-2 infection were used to classify 1,938 HIV/HSV-2 co-infected participants of the Women's Interagency HIV Study (WIHS) into groups of varying degree of HSV-2 clinical activity. Differences in plasma HIV RNA and CD4+ T cell counts between groups were explored longitudinally across three study visits and cross-sectionally at the last study visit. Results: A dose dependent association between markers of HIV disease progression and degree of HSV-2 clinical activity was observed. In multivariate analyses after adjusting for baseline CD4+ T cell levels, active HSV-2 infection with frequent symptomatic reactivations was associated with 21% to 32% increase in the probability of detectable plasma HIV RNA (trend p = 0.004), an average of 0.27 to 0.29 log10 copies/ml higher plasma HIV RNA on a continuous scale (trend p3 over time compared to asymptomatic HSV-2 infection (trend p

Original languageEnglish (US)
Article numbere9973
JournalPLoS One
Volume5
Issue number4
DOIs
StatePublished - 2010

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Human herpesvirus 2
Human Herpesvirus 2
Human immunodeficiency virus
Virus Diseases
Viruses
disease course
Disease Progression
T-cells
HIV
RNA
Plasmas
infection
T-lymphocytes
Infection
natural history
T-Lymphocytes
HIV-2
CD4 Lymphocyte Count
dosage
Natural History

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Clinical reactivations of herpes simplex virus type 2 infection and human immunodeficiency virus disease progression markers. / Aumakhan, Bulbulgul; Gaydos, Charlotte A; Quinn, Thomas C; Beyrer, Christopher; Benning, Lorie; Minkoff, Howard; Merenstein, Daniel J.; Cohen, Mardge; Greenblatt, Ruth; Nowicki, Marek; Anastos, Kathryn; Gange, Stephen J.

In: PLoS One, Vol. 5, No. 4, e9973, 2010.

Research output: Contribution to journalArticle

Aumakhan, Bulbulgul ; Gaydos, Charlotte A ; Quinn, Thomas C ; Beyrer, Christopher ; Benning, Lorie ; Minkoff, Howard ; Merenstein, Daniel J. ; Cohen, Mardge ; Greenblatt, Ruth ; Nowicki, Marek ; Anastos, Kathryn ; Gange, Stephen J. / Clinical reactivations of herpes simplex virus type 2 infection and human immunodeficiency virus disease progression markers. In: PLoS One. 2010 ; Vol. 5, No. 4.
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AU - Benning, Lorie

AU - Minkoff, Howard

AU - Merenstein, Daniel J.

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AU - Nowicki, Marek

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AU - Gange, Stephen J

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