Clinical proteomics: A need to define the field and to begin to set adequate standards

Harald Mischak, Rolf Apweiler, Rosamonde E. Banks, Mark Conaway, Joshua Coon, Anna Dominiczak, Jochen H.H. Ehrich, Danilo Fliser, Mark Girolami, Henning Hermjakob, Denis Hochstrasser, Joachim Jankowski, Bruce A. Julian, Walter Kolch, Ziad A. Massy, Christian Neusuess, Jan Novak, Karlheinz Peter, Kasper Rossing, Joost SchanstraO. John Semmes, Dan Theodorescu, Visith Thongboonkerd, Eva M. Weissinger, Jennifer E. Van Eyk, Tadashi Yamamoto

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this manuscript is to initiate a constructive discussion about the definition of clinical proteomics, study requirements, pitfalls and (potential) use. Furthermore, we hope to stimulate proposals for the optimal use of future opportunities and seek unification of the approaches in clinical proteomic studies. We have outlined our collective views about the basic principles that should be considered in clinical proteomic studies, including sample selection, choice of technology and appropriate quality control, and the need for collaborative interdisciplinary efforts involving clinicians and scientists. Furthermore, we propose guidelines for the critical aspects that should be included in published reports. Our hope is that, as a result of stimulating discussion, a consensus will be reached amongst the scientific community leading to guidelines for the studies, similar to those already published for mass spectrometric sequencing data. We contend that clinical proteomics is not just a collection of studies dealing with analysis of clinical samples. Rather, the essence of clinical proteomics should be to address clinically relevant questions and to improve the state-of-the-art, both in diagnosis and in therapy of diseases.

Original languageEnglish (US)
Pages (from-to)148-156
Number of pages9
JournalProteomics - Clinical Applications
Volume1
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Keywords

  • Biomarker
  • Clinical diagnostics
  • Protein marker discovery
  • Protein profiling
  • Proteome analysis

ASJC Scopus subject areas

  • Clinical Biochemistry

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