Clinical profile of anti-PL-12 autoantibody

Cohort study and review of the literature

Meena Kalluri, Steven A. Sahn, Chester V. Oddis, Suzanne L. Gharib, Lisa Christopher-Stine, Sonye Danoff, Livia A Casciola Rosen, Grace Hong, Paul F. Dellaripa, Kristin B. Highland

Research output: Contribution to journalArticle

Abstract

Background: The antisynthetase syndrome consists of interstitial lung disease (ILD), arthritis, myositis, fever, mechanic's hands, and Raynaud phenomenon in the presence of an antisynthetase autoantibody, most commonly anti-Jo-1. It is believed that all the antisynthetases are associated with a similar clinical profile, but definitive data in this diverse group are lacking. The purpose of this study was to examine the clinical profile of anti-PL-12, an antisynthetase autoantibody directed against alanyl-transfer RNA synthetase. Methods: Thirty-one subjects with anti-PL-12 autoantibody were identified from the databases at the Medical University of South Carolina, the University of Pittsburgh Medical Center, Johns Hopkins Medical Center, and Brigham and Women's Hospital. The medical charts were reviewed and the following data were recorded: demographic information; pulmonary and rheumatologic symptoms; connective tissue disease (CTD) diagnoses; serologic autoantibody findings; CT scan results; BAL findings; pulmonary function test results; lung histopathology; and treatment interventions. Results: The median age at symptom onset was 51 years; 81% were women and 52% were African American. Ninety percent of anti-PL-12-positive patients had ILD, 65% of whom presented initially to a pulmonologist. Ninety percent of anti-PL-12-positive patients had an underlying CTD. Polymyositis and dermatomyositis were the most common underlying diagnoses. Raynaud phenomenon occurred in 65% of patients, fever in 45% of patients, and mechanic's hands in 16% of patients. Test results for the presence of antinuclear antibody were positive in 48% of cases. Conclusions: Anti-PL-12 is strongly associated with the presence of ILD, but less so with myositis and arthritis. Idiopathic ILD diagnosed as idiopathic pulmonary fibrosis may, in fact, be associated with anti-PL-12 and be a "forme fruste" of an underlying autoimmune disorder.

Original languageEnglish (US)
Pages (from-to)1550-1556
Number of pages7
JournalChest
Volume135
Issue number6
DOIs
StatePublished - Jun 1 2009

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Autoantibodies
Interstitial Lung Diseases
Cohort Studies
Raynaud Disease
Myositis
Connective Tissue Diseases
Arthritis
Fever
Hand
Amino Acyl-tRNA Synthetases
Dimercaprol
Lung
Idiopathic Pulmonary Fibrosis
Dermatomyositis
Antinuclear Antibodies
Respiratory Function Tests
Age of Onset
African Americans
Demography
Databases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Clinical profile of anti-PL-12 autoantibody : Cohort study and review of the literature. / Kalluri, Meena; Sahn, Steven A.; Oddis, Chester V.; Gharib, Suzanne L.; Christopher-Stine, Lisa; Danoff, Sonye; Casciola Rosen, Livia A; Hong, Grace; Dellaripa, Paul F.; Highland, Kristin B.

In: Chest, Vol. 135, No. 6, 01.06.2009, p. 1550-1556.

Research output: Contribution to journalArticle

Kalluri, M, Sahn, SA, Oddis, CV, Gharib, SL, Christopher-Stine, L, Danoff, S, Casciola Rosen, LA, Hong, G, Dellaripa, PF & Highland, KB 2009, 'Clinical profile of anti-PL-12 autoantibody: Cohort study and review of the literature', Chest, vol. 135, no. 6, pp. 1550-1556. https://doi.org/10.1378/chest.08-2233
Kalluri, Meena ; Sahn, Steven A. ; Oddis, Chester V. ; Gharib, Suzanne L. ; Christopher-Stine, Lisa ; Danoff, Sonye ; Casciola Rosen, Livia A ; Hong, Grace ; Dellaripa, Paul F. ; Highland, Kristin B. / Clinical profile of anti-PL-12 autoantibody : Cohort study and review of the literature. In: Chest. 2009 ; Vol. 135, No. 6. pp. 1550-1556.
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abstract = "Background: The antisynthetase syndrome consists of interstitial lung disease (ILD), arthritis, myositis, fever, mechanic's hands, and Raynaud phenomenon in the presence of an antisynthetase autoantibody, most commonly anti-Jo-1. It is believed that all the antisynthetases are associated with a similar clinical profile, but definitive data in this diverse group are lacking. The purpose of this study was to examine the clinical profile of anti-PL-12, an antisynthetase autoantibody directed against alanyl-transfer RNA synthetase. Methods: Thirty-one subjects with anti-PL-12 autoantibody were identified from the databases at the Medical University of South Carolina, the University of Pittsburgh Medical Center, Johns Hopkins Medical Center, and Brigham and Women's Hospital. The medical charts were reviewed and the following data were recorded: demographic information; pulmonary and rheumatologic symptoms; connective tissue disease (CTD) diagnoses; serologic autoantibody findings; CT scan results; BAL findings; pulmonary function test results; lung histopathology; and treatment interventions. Results: The median age at symptom onset was 51 years; 81{\%} were women and 52{\%} were African American. Ninety percent of anti-PL-12-positive patients had ILD, 65{\%} of whom presented initially to a pulmonologist. Ninety percent of anti-PL-12-positive patients had an underlying CTD. Polymyositis and dermatomyositis were the most common underlying diagnoses. Raynaud phenomenon occurred in 65{\%} of patients, fever in 45{\%} of patients, and mechanic's hands in 16{\%} of patients. Test results for the presence of antinuclear antibody were positive in 48{\%} of cases. Conclusions: Anti-PL-12 is strongly associated with the presence of ILD, but less so with myositis and arthritis. Idiopathic ILD diagnosed as idiopathic pulmonary fibrosis may, in fact, be associated with anti-PL-12 and be a {"}forme fruste{"} of an underlying autoimmune disorder.",
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AU - Gharib, Suzanne L.

AU - Christopher-Stine, Lisa

AU - Danoff, Sonye

AU - Casciola Rosen, Livia A

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