Clinical presentation of attention-deficit/hyperactivity disorder in preschool children: The Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)

Kelly Posner, Glenn A. Melvin, Desiree W. Murray, S. Sonia Gugga, Prudence Fisher, Anne Skrobala, Charles Cunningham, Benedetto Vitiello, Howard B. Abikoff, Jaswinder K. Ghuman, Scott Kollins, Sharon B. Wigal, Tim Wigal, James T. McCracken, James J. McGough, Elizabeth Kastelic, Roy Boorady, Mark Davies, Shirley Z. Chuang, James M. SwansonMark A. Riddle, Laurence L. Greenhill

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to describe the clinical presentation of preschoolers diagnosed with moderate to severe attention-deficit/ hyperactivity disorder (ADHD) recruited for the multisite Preschool ADHD Treatment Study (PATS). The diagnosis and evaluation process will also be described. Method: A comprehensive multidimensional, multi-informant assessment protocol was implemented including the semistructured PATS Diagnostic Interview. Parent and teacher-report measures were used to supplement information from interviews. Consensus agreement by a cross-site panel on each participant's diagnoses was required. Analyses were conducted to describe the sample and to test associations between ADHD severity and demographic and clinical variables. Results: The assessment protocol identified 303 preschoolers (3-5.5 years) with moderate to severe ADHD Hyperactive/Impulsive or Combined type. The majority of participants (n = 211, 69.6%) experienced co-morbid disorders, with oppositional defiant disorder, communication disorders, and anxiety disorders being the most common. Participants with co-morbid communication disorders were found to be more anxious and depressed. ADHD severity was found to correlate with more internalizing difficulties and lower functioning. Although boys and girls had similar symptom presentations, younger children had significantly higher ADHD severity. Conclusions: Preschoolers with moderate to severe ADHD experience high co-morbidity and impairment, which have implications for both assessment and treatment.

Original languageEnglish (US)
Pages (from-to)547-562
Number of pages16
JournalJournal of child and adolescent psychopharmacology
Volume17
Issue number5
DOIs
StatePublished - Nov 1 2007

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Posner, K., Melvin, G. A., Murray, D. W., Gugga, S. S., Fisher, P., Skrobala, A., Cunningham, C., Vitiello, B., Abikoff, H. B., Ghuman, J. K., Kollins, S., Wigal, S. B., Wigal, T., McCracken, J. T., McGough, J. J., Kastelic, E., Boorady, R., Davies, M., Chuang, S. Z., ... Greenhill, L. L. (2007). Clinical presentation of attention-deficit/hyperactivity disorder in preschool children: The Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS). Journal of child and adolescent psychopharmacology, 17(5), 547-562. https://doi.org/10.1089/cap.2007.0075