Clinical presentation and differential diagnosis of dementia with Lewy bodies: A review

L. F. Morra, P. J. Donovick

Research output: Contribution to journalReview article

Abstract

Background Dementia with Lewy bodies is one of the most prevalent dementia diagnoses. However, differential diagnosis between dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease with dementia can still be very difficult given the overlap in neuropathology, clinical presentation, cognitive, and neuroanatomical changes. Method A literature review of dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease with dementia was conducted using PubMed. Results and Implications Accurate diagnosis of dementia with Lewy bodies is crucial in order to more accurately predict the progression of the disease and negative side effects from pharmacological treatment. The differences and similarities between dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease with dementia are highlighted in order to aid clinicians in differential diagnosis.

Original languageEnglish (US)
Pages (from-to)569-576
Number of pages8
JournalInternational journal of geriatric psychiatry
Volume29
Issue number6
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • aging
  • alpha synucleins
  • dementia
  • dementia with Lewy bodies
  • differential diagnosis

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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