TY - JOUR
T1 - Clinical predictors of critical lower respiratory tract illness due to respiratory syncytial virus in infants and children
T2 - Data to inform case definitions for efficacy trials
AU - Atwell, Jessica E.
AU - Geoghegan, Sarah
AU - Karron, Ruth A.
AU - Polack, Fernando P.
N1 - Publisher Copyright:
© 2016 The Author.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - We analyzed data from 524 Argentinean infants hospitalized with lower respiratory tract illness (LRTI) due to respiratory syncytial virus (RSV) to inform selection of clinical end points for RSV vaccine efficacy trials. Cases of LRTI due to RSV that required a mask, continuous or bilevel positive airway pressure, or mechanical ventilation were classified as critical. Oxygen saturation of =90%, tachypnea, and tachycardia were each associated with an increased odds of critical LRTI due to RSV (adjusted odds ratios [ORs], 2.30 [95% confidence interval {CI}, 1.26-4.24; P =.007], 2.22 [95% CI, 1.19-4.16; P =.012], and 2.35 [95% CI, 1.22-4.50; P =.010], respectively). The odds of critical LRTI due to RSV increased substantially (OR, 8.57; 95% CI, 2.19-73.5; P =.001) among individuals with ≥2 indicators. Lower chest wall indrawing was not associated with critical disease.
AB - We analyzed data from 524 Argentinean infants hospitalized with lower respiratory tract illness (LRTI) due to respiratory syncytial virus (RSV) to inform selection of clinical end points for RSV vaccine efficacy trials. Cases of LRTI due to RSV that required a mask, continuous or bilevel positive airway pressure, or mechanical ventilation were classified as critical. Oxygen saturation of =90%, tachypnea, and tachycardia were each associated with an increased odds of critical LRTI due to RSV (adjusted odds ratios [ORs], 2.30 [95% confidence interval {CI}, 1.26-4.24; P =.007], 2.22 [95% CI, 1.19-4.16; P =.012], and 2.35 [95% CI, 1.22-4.50; P =.010], respectively). The odds of critical LRTI due to RSV increased substantially (OR, 8.57; 95% CI, 2.19-73.5; P =.001) among individuals with ≥2 indicators. Lower chest wall indrawing was not associated with critical disease.
KW - Case definitions
KW - Clinical development
KW - Respiratory syncytial virus
KW - Vaccine
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U2 - 10.1093/infdis/jiw447
DO - 10.1093/infdis/jiw447
M3 - Article
C2 - 27655869
AN - SCOPUS:85014734536
SN - 0022-1899
VL - 214
SP - 1712
EP - 1716
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -