Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

L. Clifford McDonald, Dale N. Gerding, Stuart Johnson, Johan S. Bakken, Karen C Carroll, Susan E. Coffin, Erik R. Dubberke, Kevin W. Garey, Carolyn V. Gould, Ciaran Kelly, Vivian Loo, Julia Shaklee Sammons, Thomas J. Sandora, Mark H. Wilcox

Research output: Contribution to journalReview article


A panel of experts was convened by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) to update the 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations for children (following the adult recommendations for epidemiology, diagnosis, and treatment), includes significant changes in the management of this infection and reflects the evolving controversy over best methods for diagnosis. Clostridium difficile remains the most important cause of healthcare-associated diarrhea and has become the most commonly identified cause of healthcare-associated infection in adults in the United States. Moreover, C. difficile has established itself as an important community pathogen. Although the prevalence of the epidemic and virulent ribotype 027 strain has declined markedly along with overall CDI rates in parts of Europe, it remains one of the most commonly identified strains in the United States where it causes a sizable minority of CDIs, especially healthcare-associated CDIs. This guideline updates recommendations regarding epidemiology, diagnosis, treatment, infection prevention, and environmental management.

Original languageEnglish (US)
Pages (from-to)987-994
Number of pages8
JournalClinical Infectious Diseases
Issue number7
Publication statusPublished - Mar 19 2018



  • CDAD
  • CDI
  • Clostridioides difficile
  • Clostridium difficile
  • Guidelines

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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