Clinical pharmacology in HIV therapy

Mohamed G. Atta, Sophie De Seigneux, Gregory M. Lucas

Research output: Contribution to journalArticle

Abstract

The success of combination antiretroviral therapy in the treatment ofHIV-1-positive individuals has shifted clinical attention toward combination antiretroviral drug regimens that optimize tolerability, long-term safety, and durable efficacy.Wherever patients have access to treatment, morbidity and mortality are increasingly driven by non-HIV-associated comorbidities, which may be observed earlier than in age-matched controls and despite the best available combination antiretroviral therapy. Similarly, HIV-1-positive individuals are now diagnosed and treated earlier with anticipated lifelong therapy. The contribution of specific antiretroviral agents to long-term morbidity and mortality is dependent on the pharmacologic characteristics of these agents, and it is increasingly important in this context.

Original languageEnglish (US)
Pages (from-to)435-444
Number of pages10
JournalClinical Journal of the American Society of Nephrology
Volume14
Issue number3
DOIs
StatePublished - Mar 7 2019

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ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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