TY - JOUR
T1 - Clinical Pharmacokinetics of the Newer Benzodiazepines
AU - Greenblatt, David J.
AU - Divoll, Marcia
AU - Abernethy, Darrell R.
AU - Ochs, Hermann R.
AU - Shader, Richard I.
PY - 1983/6
Y1 - 1983/6
N2 - New benzodiazepine derivatives continue to be developed and introduced into clinical use. The pharmacokinetic properties of these newer drugs can best be understood by their categorisation according to range of elimination half-life and pathway of metabolism (oxidation versus conjugation). Clobazam and halazepam are long half-life (and therefore accumulating) anxiolytics metabolised by oxidation. Alprazolam and clotiazepam also are oxidised compounds but have short to intermediate half-life values and therefore produce considerably less accumulation. Temazepam and lormetazepam are hypnotic agents with intermediate half-lives but metabolised by conjugation. The most unique of the newer benzodiazepines are the ultra-short half-life (oxidised) compounds midazolam, triazolam and brotizolam, which are essentially non-accumulating during multiple dosage.
AB - New benzodiazepine derivatives continue to be developed and introduced into clinical use. The pharmacokinetic properties of these newer drugs can best be understood by their categorisation according to range of elimination half-life and pathway of metabolism (oxidation versus conjugation). Clobazam and halazepam are long half-life (and therefore accumulating) anxiolytics metabolised by oxidation. Alprazolam and clotiazepam also are oxidised compounds but have short to intermediate half-life values and therefore produce considerably less accumulation. Temazepam and lormetazepam are hypnotic agents with intermediate half-lives but metabolised by conjugation. The most unique of the newer benzodiazepines are the ultra-short half-life (oxidised) compounds midazolam, triazolam and brotizolam, which are essentially non-accumulating during multiple dosage.
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U2 - 10.2165/00003088-198308030-00003
DO - 10.2165/00003088-198308030-00003
M3 - Article
C2 - 6133664
AN - SCOPUS:0020536610
SN - 0312-5963
VL - 8
SP - 233
EP - 252
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
IS - 3
ER -