Clinical Outcomes of Patients with Vogt–Koyanagi–Harada Disease Over 12 Years at a Tertiary Center

J Fernando Arevalo, Andres F. Lasave, Vishali Gupta, Igor Kozak, Mosa Barakat Al Harbi, Abdulaziz Adel Al Rushood, Hassan A. Al Dhibi

Research output: Contribution to journalArticle

Abstract

Purpose: To describe the clinical characteristics and treatment outcomes of Vogt–Koyanagi–Harada (VKH) disease over a 12-year period. Methods: A retrospective chart review was used to identify VKH patients, from January 1999 to December 2011. Results: In total, 154 patients (308 eyes) were diagnosed with VKH. The mean age at diagnosis was 33.8 ± 13 years. Mean baseline best-corrected visual acuity (BCVA) was 20/125; (0.8 ± 0.6 logMAR). Recurrent episodes occurred in 107 (54%) patients. Oral prednisone was administered in all patients. At the last visit, the mean BCVA was 20/50 (0.4 ± 0.7 logMAR). The most common complications post-treatment were: glaucoma [104 (33.8%) eyes] and cataract [84 (27.2%) eyes]. Conclusions: In Saudi Arabia, VKH-related uveitis is predominant in young females. Bilateral panuveitis is the most common ocular manifestation and near 50% of eyes present with exudative retinal detachment. Oral prednisone was the primary treatment and the majority of eyes maintained 20/50 or better vision.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
DOIs
StateAccepted/In press - Sep 22 2015

Fingerprint

Prednisone
Visual Acuity
Eye Manifestations
Panuveitis
Saudi Arabia
Uveitis
Retinal Detachment
Glaucoma
Cataract
Therapeutics

Keywords

  • Panuveitis
  • prednisone
  • Saudi Arabia
  • uveitis
  • Vogt–Koyanagi–Harada disease

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

Cite this

Clinical Outcomes of Patients with Vogt–Koyanagi–Harada Disease Over 12 Years at a Tertiary Center. / Arevalo, J Fernando; Lasave, Andres F.; Gupta, Vishali; Kozak, Igor; Al Harbi, Mosa Barakat; Al Rushood, Abdulaziz Adel; Al Dhibi, Hassan A.

In: Ocular Immunology and Inflammation, 22.09.2015.

Research output: Contribution to journalArticle

Arevalo, J Fernando ; Lasave, Andres F. ; Gupta, Vishali ; Kozak, Igor ; Al Harbi, Mosa Barakat ; Al Rushood, Abdulaziz Adel ; Al Dhibi, Hassan A. / Clinical Outcomes of Patients with Vogt–Koyanagi–Harada Disease Over 12 Years at a Tertiary Center. In: Ocular Immunology and Inflammation. 2015.
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abstract = "Purpose: To describe the clinical characteristics and treatment outcomes of Vogt–Koyanagi–Harada (VKH) disease over a 12-year period. Methods: A retrospective chart review was used to identify VKH patients, from January 1999 to December 2011. Results: In total, 154 patients (308 eyes) were diagnosed with VKH. The mean age at diagnosis was 33.8 ± 13 years. Mean baseline best-corrected visual acuity (BCVA) was 20/125; (0.8 ± 0.6 logMAR). Recurrent episodes occurred in 107 (54{\%}) patients. Oral prednisone was administered in all patients. At the last visit, the mean BCVA was 20/50 (0.4 ± 0.7 logMAR). The most common complications post-treatment were: glaucoma [104 (33.8{\%}) eyes] and cataract [84 (27.2{\%}) eyes]. Conclusions: In Saudi Arabia, VKH-related uveitis is predominant in young females. Bilateral panuveitis is the most common ocular manifestation and near 50{\%} of eyes present with exudative retinal detachment. Oral prednisone was the primary treatment and the majority of eyes maintained 20/50 or better vision.",
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