Clinical Outcomes after Treatment of Germ Cell Tumors

Christopher Jackson, George Jallo, Michael Lim

Research output: Contribution to journalReview article

Abstract

Intracranial GCTs are a heterogeneous group of neoplasms most commonly diagnosed in the pediatric population. Germinomas are exquisitely radiosensitive with long-term survival rates in excess of 90% with radiotherapy alone. NGGCTs are associated with a poorer prognosis and are typically treated with a combination of radiation and chemotherapy. Given the young age of these patients, achieving optimal outcomes will ultimately require a careful balance of maximizing disease control while minimizing adverse treatment effects. Here we review the management of intracranial GCTs and discuss the clinical outcomes of patients who undergo treatment for these rare and fascinating tumors.

Original languageEnglish (US)
Pages (from-to)385-394
Number of pages10
JournalNeurosurgery clinics of North America
Volume22
Issue number3
DOIs
StatePublished - Jul 1 2011

Keywords

  • Germ cell tumors
  • Germinomas
  • Intracranial GCTs
  • Nongerminomatous germ cell tumors

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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