Clinical, neuropathologic and pharmacologic aspects of Huntington's disease: Correlates with a new animal model

J. T. Coyle, R. Schwarcz, J. P. Bennett, P. Campochiaro

Research output: Contribution to journalArticle

Abstract

1. 1. Huntington's disease (HD) is a neurologic disorder inherited in an autosomal dominant fashion that is characterized by dementia and a movement disorder. 2. 2. The movement dysfunction appears to be due to degeneration of neurons intrinsic to the striatum resulting in a functional imbalance between the intact dopaminergic input and the paucity of cholinergic and GABA-ergic neurons in the striatum. Similar neurochemical and histologic alterations in the nigro-striatal axis can be produced in rats by stereotaxic injection of kainic acid, a rigid analogue of glutamate, into the corpus striatum. 3. 3. The animal model of HD resulting from the striatal kainate lesions offers opportunities for better understanding the pathophysiology of HD as well as for testing pharmacologic agents that may correct neurotransmitter imbalances of HD. The kainate induced lesion suggests testable hypotheses concerning the fundamental defect in HD.

Original languageEnglish (US)
Pages (from-to)13-30
Number of pages18
JournalProgress in Neuro-Psychopharmacology
Volume1
Issue number1-2
DOIs
StatePublished - 1977

Keywords

  • Huntington's disease
  • acetylcholine
  • kainic acid
  • neurotransmitter-receptors
  • striatum
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health
  • Pharmacology (medical)

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