Clinical manifestations and modes of death among patients with Ebola virus disease, Monrovia, Liberia, 2014

Linda M. Mobula, Nathalie MacDermott, Clive Hoggart, Kent Brantly, William Plyler, Jerry Brown, Bev Kauffeldt, Deborah Eisenhut, Lisa A Cooper, John Fankhauser

Research output: Contribution to journalArticle

Abstract

Although the high case fatality rate (CFR) associated with Ebola virus disease (EVD) is well documented, there are limited data on the actual modes of death. We conducted a retrospective, observational cohort study among patients with laboratory-confirmed EVD. The patients were all seen at the Eternal Love Winning Africa Ebola Treatment Unit in Monrovia, Liberia, from June to August 2014. Our primary objective was to describe the modes of death of our patients and to determine predictors of mortality. Data were available for 53 patients with laboratory-confirmed EVD, with a median age of 35 years. The most frequent presenting symptoms were weakness (91%), fever (81%), and diarrhea (78%). Visible hemorrhage was noted in 25% of the cases. The CFR was 79%. Odds of death were higher in patients with diarrhea (odds ratio = 26.1, P < 0.01). All patients with hemorrhagic signs died (P < 0.01). Among the 18 fatal cases for which clinical information was available, three distinct modes of death were observed: Sudden death after a moderate disease process (44%), profuse hemorrhage (33%), and encephalopathy (22%). We found that these modes of death varied by age (P = 0.04), maximum temperature (P = 0.43), heart rate on admission (P = 0.04), time to death from symptom onset (P = 0.13), and duration of hospitalization (P = 0.04). Although further study is required, our findings provide a foundation for developing treatment strategies that factor in patients with specific disease phenotypes (which often require the use of aggressive hydration). These findings provide insights into underlying pathogenic mechanisms resulting in severe EVD and suggest direction for future research and development of effective treatment options.

Original languageEnglish (US)
Pages (from-to)1186-1193
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number4
DOIs
StatePublished - Jan 1 2018

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Ebola Hemorrhagic Fever
Liberia
Mortality
Diarrhea
Hemorrhage
Love
Brain Diseases
Sudden Death
Observational Studies
Hospitalization
Cohort Studies
Fever
Therapeutics
Heart Rate
Odds Ratio
Phenotype
Temperature

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Mobula, L. M., MacDermott, N., Hoggart, C., Brantly, K., Plyler, W., Brown, J., ... Fankhauser, J. (2018). Clinical manifestations and modes of death among patients with Ebola virus disease, Monrovia, Liberia, 2014. American Journal of Tropical Medicine and Hygiene, 98(4), 1186-1193. https://doi.org/10.4269/ajtmh.17-0090

Clinical manifestations and modes of death among patients with Ebola virus disease, Monrovia, Liberia, 2014. / Mobula, Linda M.; MacDermott, Nathalie; Hoggart, Clive; Brantly, Kent; Plyler, William; Brown, Jerry; Kauffeldt, Bev; Eisenhut, Deborah; Cooper, Lisa A; Fankhauser, John.

In: American Journal of Tropical Medicine and Hygiene, Vol. 98, No. 4, 01.01.2018, p. 1186-1193.

Research output: Contribution to journalArticle

Mobula, LM, MacDermott, N, Hoggart, C, Brantly, K, Plyler, W, Brown, J, Kauffeldt, B, Eisenhut, D, Cooper, LA & Fankhauser, J 2018, 'Clinical manifestations and modes of death among patients with Ebola virus disease, Monrovia, Liberia, 2014', American Journal of Tropical Medicine and Hygiene, vol. 98, no. 4, pp. 1186-1193. https://doi.org/10.4269/ajtmh.17-0090
Mobula, Linda M. ; MacDermott, Nathalie ; Hoggart, Clive ; Brantly, Kent ; Plyler, William ; Brown, Jerry ; Kauffeldt, Bev ; Eisenhut, Deborah ; Cooper, Lisa A ; Fankhauser, John. / Clinical manifestations and modes of death among patients with Ebola virus disease, Monrovia, Liberia, 2014. In: American Journal of Tropical Medicine and Hygiene. 2018 ; Vol. 98, No. 4. pp. 1186-1193.
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