Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: Data from an international inception cohort

Murray B. Urowitz, D. Gladman, D. Ibañez, P. Fortin, J. Sanchez-Guerrero, S. Bae, A. Clarke, S. Bernatsky, C. Gordon, J. Hanly, D. Wallace, D. Isenberg, E. Ginzler, J. Merrill, G. Alarcon, K. Steinsson, M. Petri, M. A. Dooley, I. Bruce, S. ManziM. Khamashta, R. Ramsey-Goldman, A. Zoma, G. Sturfelt, O. Nived, P. Maddison, J. Font, R. Van Vollenhoven, C. Aranow, K. Kalunian, T. Stoll, J. Buyon

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.

Original languageEnglish (US)
Pages (from-to)731-735
Number of pages5
JournalLupus
Volume16
Issue number9
DOIs
StatePublished - Oct 9 2007
Externally publishedYes

Keywords

  • Coronary artery risk factors
  • Inception observation cohort study
  • Lupus

ASJC Scopus subject areas

  • Rheumatology

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