Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: Data from an international inception cohort

Murray B. Urowitz, D. Gladman, D. Ibañez, P. Fortin, J. Sanchez-Guerrero, S. Bae, A. Clarke, S. Bernatsky, C. Gordon, J. Hanly, D. Wallace, D. Isenberg, E. Ginzler, J. Merrill, G. Alarcon, K. Steinsson, Michelle Petri, M. A. Dooley, I. Bruce, S. ManziM. Khamashta, R. Ramsey-Goldman, A. Zoma, G. Sturfelt, O. Nived, P. Maddison, J. Font, R. Van Vollenhoven, C. Aranow, K. Kalunian, T. Stoll, J. Buyon

Research output: Contribution to journalArticle

Abstract

Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.

Original languageEnglish (US)
Pages (from-to)731-735
Number of pages5
JournalLupus
Volume16
Issue number9
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Coronary Artery Disease
Atherosclerosis
Hypercholesterolemia
Registries
Hypertension
Education

Keywords

  • Coronary artery risk factors
  • Inception observation cohort study
  • Lupus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus : Data from an international inception cohort. / Urowitz, Murray B.; Gladman, D.; Ibañez, D.; Fortin, P.; Sanchez-Guerrero, J.; Bae, S.; Clarke, A.; Bernatsky, S.; Gordon, C.; Hanly, J.; Wallace, D.; Isenberg, D.; Ginzler, E.; Merrill, J.; Alarcon, G.; Steinsson, K.; Petri, Michelle; Dooley, M. A.; Bruce, I.; Manzi, S.; Khamashta, M.; Ramsey-Goldman, R.; Zoma, A.; Sturfelt, G.; Nived, O.; Maddison, P.; Font, J.; Van Vollenhoven, R.; Aranow, C.; Kalunian, K.; Stoll, T.; Buyon, J.

In: Lupus, Vol. 16, No. 9, 2007, p. 731-735.

Research output: Contribution to journalArticle

Urowitz, MB, Gladman, D, Ibañez, D, Fortin, P, Sanchez-Guerrero, J, Bae, S, Clarke, A, Bernatsky, S, Gordon, C, Hanly, J, Wallace, D, Isenberg, D, Ginzler, E, Merrill, J, Alarcon, G, Steinsson, K, Petri, M, Dooley, MA, Bruce, I, Manzi, S, Khamashta, M, Ramsey-Goldman, R, Zoma, A, Sturfelt, G, Nived, O, Maddison, P, Font, J, Van Vollenhoven, R, Aranow, C, Kalunian, K, Stoll, T & Buyon, J 2007, 'Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: Data from an international inception cohort', Lupus, vol. 16, no. 9, pp. 731-735. https://doi.org/10.1177/0961203307081113
Urowitz, Murray B. ; Gladman, D. ; Ibañez, D. ; Fortin, P. ; Sanchez-Guerrero, J. ; Bae, S. ; Clarke, A. ; Bernatsky, S. ; Gordon, C. ; Hanly, J. ; Wallace, D. ; Isenberg, D. ; Ginzler, E. ; Merrill, J. ; Alarcon, G. ; Steinsson, K. ; Petri, Michelle ; Dooley, M. A. ; Bruce, I. ; Manzi, S. ; Khamashta, M. ; Ramsey-Goldman, R. ; Zoma, A. ; Sturfelt, G. ; Nived, O. ; Maddison, P. ; Font, J. ; Van Vollenhoven, R. ; Aranow, C. ; Kalunian, K. ; Stoll, T. ; Buyon, J. / Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus : Data from an international inception cohort. In: Lupus. 2007 ; Vol. 16, No. 9. pp. 731-735.
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AU - Urowitz, Murray B.

AU - Gladman, D.

AU - Ibañez, D.

AU - Fortin, P.

AU - Sanchez-Guerrero, J.

AU - Bae, S.

AU - Clarke, A.

AU - Bernatsky, S.

AU - Gordon, C.

AU - Hanly, J.

AU - Wallace, D.

AU - Isenberg, D.

AU - Ginzler, E.

AU - Merrill, J.

AU - Alarcon, G.

AU - Steinsson, K.

AU - Petri, Michelle

AU - Dooley, M. A.

AU - Bruce, I.

AU - Manzi, S.

AU - Khamashta, M.

AU - Ramsey-Goldman, R.

AU - Zoma, A.

AU - Sturfelt, G.

AU - Nived, O.

AU - Maddison, P.

AU - Font, J.

AU - Van Vollenhoven, R.

AU - Aranow, C.

AU - Kalunian, K.

AU - Stoll, T.

AU - Buyon, J.

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