Clinical laboratory methods for the assessment and management of human allergic diseases

Research output: Contribution to journalArticle

Abstract

The objective of this article is to review our current understanding of the role of IgE (reaginic) antibodies in immediate hypersensitivity (allergic) reactions in humans and to summarize recent approaches in the laboratory diagnosis and management of human allergic diseases. Quantitative assays for total and allergen-specific IgE antibodies will be discussed within the context of their use in diagnosis. The RAST (radioallergosorbent test) inhibition assay and specific IgG antibody assays will then be described as methods useful in the planning and monitoring of hyposensitization regimens (immunotherapy).

Original languageEnglish (US)
Pages (from-to)117-138
Number of pages22
JournalClinics in Laboratory Medicine
Volume6
Issue number1
StatePublished - 1986
Externally publishedYes

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Clinical laboratories
Assays
Immunoglobulin E
Antibodies
Radioallergosorbent Test
Immediate Hypersensitivity
Clinical Laboratory Techniques
Immunotherapy
Allergens
Hypersensitivity
Immunoglobulin G
Planning
Monitoring

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

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abstract = "The objective of this article is to review our current understanding of the role of IgE (reaginic) antibodies in immediate hypersensitivity (allergic) reactions in humans and to summarize recent approaches in the laboratory diagnosis and management of human allergic diseases. Quantitative assays for total and allergen-specific IgE antibodies will be discussed within the context of their use in diagnosis. The RAST (radioallergosorbent test) inhibition assay and specific IgG antibody assays will then be described as methods useful in the planning and monitoring of hyposensitization regimens (immunotherapy).",
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