Clinical insights into the origins of thrombosis in myeloproliferative neoplasms

Alison R. Moliterno, Yelena Z. Ginzburg, Ronald Hoffman

Research output: Contribution to journalReview articlepeer-review

Abstract

Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are hematopoietic stem cell disorders that are defined by activating mutations in signal transduction pathways and are characterized clinically by the overproduction of platelets, red blood cells, and neutrophils, significant burden of disease-specific symptoms, and high rates of vascular events. The focus of this review is to critically reevaluate the clinical burden of thrombosis in MPNs, to review the clinical associations among clonal hematopoiesis, JAK2V617F burden, inflammation, and thrombosis, and to provide insights into novel primary and secondary thrombosis-prevention strategies.

Original languageEnglish (US)
Pages (from-to)1145-1153
Number of pages9
JournalBlood
Volume137
Issue number9
DOIs
StatePublished - Mar 4 2021

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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