Clinical implications of molecular markers in acute myeloid leukemia

Sabine Kayser, Mark J. Levis

Research output: Contribution to journalReview articlepeer-review

Abstract

The recently updated World Health Organization (WHO) Classification of myeloid neoplasms and leukemia reflects the fact that research in the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has led to remarkable advances in our understanding of the disease. Gene mutations now allow us to explore the enormous diversity among cytogenetically defined subsets of AML, particularly the large subset of cytogenetically normal AML. Despite the progress in unraveling the tumor genome, only a small number of recurrent mutations have been incorporated into risk-stratification schemes and have been proven to be clinically relevant, targetable lesions. We here discuss the utility of molecular markers in AML in prognostication and treatment decision making, specifically highlighting the aberrations included in the current WHO classification.

Original languageEnglish (US)
Pages (from-to)20-35
Number of pages16
JournalEuropean Journal of Haematology
Volume102
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • acute myeloid leukemia
  • molecular markers
  • prognostic impact

ASJC Scopus subject areas

  • Hematology

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