It has long been known that some cellular proteins bind guanine nucleotides such as guanosine triphosphate (GTP) with high affinity. These binding proteins are called G proteins and have been linked to such critical intracellular functions as protein synthesis. In the past decade three new G proteins have been discovered that reside in the plasma membrane and transmit information from the outside to the inside of the cell. Two of these new G proteins form part of the adenylate cyclase system, a membrane-bound enzyme complex found in virtually every cell, and the third G protein is found in the disk membranes of the outer segment of the retinal rod. In this review we will discuss this new family of G proteins, beginning with their structural and functional features. We will then explore the clinical implications of G-protein abnormalities and discuss disorders, such as cholera and pseudohypoparathyroidism, that have been clearly linked to abnormalities of these proteins. In addition, we will examine other disorders that may involve G proteins, such as retinitis pigmentosa.
|Original language||English (US)|
|Number of pages||8|
|Journal||New England Journal of Medicine|
|State||Published - 1985|
ASJC Scopus subject areas