Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience

Christina L. Aquilante, David P. Kao, Katy E. Trinkley, Chen Tan Lin, Kristy R. Crooks, Emily C. Hearst, Steven J. Hess, Elizabeth L. Kudron, Yee Ming Lee, Ina Liko, Jan Lowery, Rasika A. Mathias, Andrew A. Monte, Nicholas Rafaels, Matthew J. Rioth, Emily R. Roberts, Matthew R.G. Taylor, Connie Williamson, Kathleen C. Barnes

Research output: Contribution to journalArticlepeer-review

Abstract

In recent years, the genomics community has witnessed the growth of large research biobanks, which collect DNA samples for research purposes. Depending on how and where the samples are genotyped, biobanks also offer the potential opportunity to return actionable genomic results to the clinical setting. We developed a preemptive clinical pharmacogenomic implementation initiative via a health system-wide research biobank at the University of Colorado. Here, we describe how preemptive return of clinical pharmacogenomic results via a research biobank is feasible, particularly when coupled with strong institutional support to maximize the impact and efficiency of biobank resources, a multidisciplinary implementation team, automated clinical decision support tools, and proactive strategies to engage stakeholders early in the clinical decision support tool development process.

Original languageEnglish (US)
Pages (from-to)375-386
Number of pages12
JournalPharmacogenomics
Volume21
Issue number6
DOIs
StatePublished - Apr 2020

Keywords

  • biobank
  • implementation
  • personalized medicine
  • pharmacogenetics
  • pharmacogenomics
  • precision medicine

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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