Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols

H. F A Vasen; B. G. Taal; G. Griffioen; F. M. Nagengast; A. Cats; F. H. Menko; W. Oskam; J. H. Kleibeuker; G. J A Offerhaus; P. Meera Khan

Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols

H. F A Vasen, B. G. Taal, G. Griffioen, F. M. Nagengast, A. Cats, F. H. Menko, W. Oskam, J. H. Kleibeuker, G. J A Offerhaus, P. Meera Khan

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43 Scopus citations

Abstract

The age at onset of non-polyposis colorectal cancer (CRC) was investigated in 49 families with at least three relatives affected in two successive generations. Forty one of these families satisfy the accepted minimum criteria for hereditary non-polyposis CRC. The remaining eight families were distinguished by a late age of disease onset and, hence, could not be included in the group. The condition in these latter families has been designated provisionally, as late onset familial CRC. The hereditary non-polyposis CRC families include 194 patients, 110 men and 84 women (mean age at diagnosis: 44 years; range: 16-74 years). Ninety two per cent of the patients were diagnosed by age 60. Colorectal cancer was diagnosed at progressively earlier ages in successive generations (p

Original language	English (US)
Pages (from-to)	1262-1266
Number of pages	5
Journal	Gut
Volume	35
Issue number	9
State	Published - Sep 1994
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology
Public Health, Environmental and Occupational Health

Cite this

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title = "Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols",

abstract = "The age at onset of non-polyposis colorectal cancer (CRC) was investigated in 49 families with at least three relatives affected in two successive generations. Forty one of these families satisfy the accepted minimum criteria for hereditary non-polyposis CRC. The remaining eight families were distinguished by a late age of disease onset and, hence, could not be included in the group. The condition in these latter families has been designated provisionally, as late onset familial CRC. The hereditary non-polyposis CRC families include 194 patients, 110 men and 84 women (mean age at diagnosis: 44 years; range: 16-74 years). Ninety two per cent of the patients were diagnosed by age 60. Colorectal cancer was diagnosed at progressively earlier ages in successive generations (p",

author = "Vasen, {H. F A} and Taal, {B. G.} and G. Griffioen and Nagengast, {F. M.} and A. Cats and Menko, {F. H.} and W. Oskam and Kleibeuker, {J. H.} and Offerhaus, {G. J A} and {Meera Khan}, P.",

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T1 - Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols

AU - Vasen, H. F A

AU - Taal, B. G.

AU - Griffioen, G.

AU - Nagengast, F. M.

AU - Cats, A.

AU - Menko, F. H.

AU - Oskam, W.

AU - Kleibeuker, J. H.

AU - Offerhaus, G. J A

AU - Meera Khan, P.

PY - 1994/9

Y1 - 1994/9

N2 - The age at onset of non-polyposis colorectal cancer (CRC) was investigated in 49 families with at least three relatives affected in two successive generations. Forty one of these families satisfy the accepted minimum criteria for hereditary non-polyposis CRC. The remaining eight families were distinguished by a late age of disease onset and, hence, could not be included in the group. The condition in these latter families has been designated provisionally, as late onset familial CRC. The hereditary non-polyposis CRC families include 194 patients, 110 men and 84 women (mean age at diagnosis: 44 years; range: 16-74 years). Ninety two per cent of the patients were diagnosed by age 60. Colorectal cancer was diagnosed at progressively earlier ages in successive generations (p

AB - The age at onset of non-polyposis colorectal cancer (CRC) was investigated in 49 families with at least three relatives affected in two successive generations. Forty one of these families satisfy the accepted minimum criteria for hereditary non-polyposis CRC. The remaining eight families were distinguished by a late age of disease onset and, hence, could not be included in the group. The condition in these latter families has been designated provisionally, as late onset familial CRC. The hereditary non-polyposis CRC families include 194 patients, 110 men and 84 women (mean age at diagnosis: 44 years; range: 16-74 years). Ninety two per cent of the patients were diagnosed by age 60. Colorectal cancer was diagnosed at progressively earlier ages in successive generations (p

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Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols

Abstract

ASJC Scopus subject areas

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