Clinical heterogeneity of familial colorectal cancer and its influence on screening protocols

H. F A Vasen, B. G. Taal, G. Griffioen, F. M. Nagengast, A. Cats, F. H. Menko, W. Oskam, J. H. Kleibeuker, G. J A Offerhaus, P. Meera Khan

Research output: Contribution to journalArticlepeer-review

Abstract

The age at onset of non-polyposis colorectal cancer (CRC) was investigated in 49 families with at least three relatives affected in two successive generations. Forty one of these families satisfy the accepted minimum criteria for hereditary non-polyposis CRC. The remaining eight families were distinguished by a late age of disease onset and, hence, could not be included in the group. The condition in these latter families has been designated provisionally, as late onset familial CRC. The hereditary non-polyposis CRC families include 194 patients, 110 men and 84 women (mean age at diagnosis: 44 years; range: 16-74 years). Ninety two per cent of the patients were diagnosed by age 60. Colorectal cancer was diagnosed at progressively earlier ages in successive generations (p

Original languageEnglish (US)
Pages (from-to)1262-1266
Number of pages5
JournalGut
Volume35
Issue number9
StatePublished - Sep 1994
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology
  • Public Health, Environmental and Occupational Health

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